1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

Base Information

Chemical Name:1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole
CAS No.:79309-83-4
Molecular Formula:C₁₉H₁₇NO₄
Molecular Weight:323.348
Hs Code.:

1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenz<cd>indole

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

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Technology Process of 1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

There total 6 articles about 1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 79309-79-8
3-(1'-benzoyl-5',6'-dimethoxy-3'-indolinyl)propanoic acid

: 79309-83-4
1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

: 79309-82-3
1-benzoyl-6,7-dimethoxy-5-keto-1,2,2a,3,4,5-hexahydrobenzindole

Guidance literature:: With PPA; at 85 ℃; for 1h;
DOI:10.1016/S0040-4020(01)98949-5

Reference yield:

: 17354-04-0
2-(4,5-dimethoxy-2-nitrophenyl)acetonitrile

: 79309-83-4
1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / 40percent Triton B / ethanol; dioxane; methanol / 1.) 2.5h, 80-85 deg C, 2.) 40-50 deg C

2: 78 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / 80 °C

3: 87.6 percent / NaOH / dioxane; H₂O / 2 h / Heating

4: borane-pyridine complex, 12.5percent HCl; 2.) aq. NaOH / 1.) methanol, ice-water bath, 25 min, then 4h, then 20-30 min; 2.) 1h

5: 12 percent / polyphosphoric acid / 1 h / 85 °C

With hydrogenchloride; sodium hydroxide; PPA; borane pyridine; hydrogen; N-benzyl-trimethylammonium hydroxide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)98949-5

Reference yield:

: 79309-75-4
ethyl 4-cyano-4-(4',5'-dimethoxy-2'-nitrophenyl)butyrate

: 79309-83-4
1-benzoyl-6-hydroxy-5-keto-7-methoxy-1,2,2a,3,4,5-hexahydrobenzindole

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h / 80 °C

2: 87.6 percent / NaOH / dioxane; H₂O / 2 h / Heating

3: borane-pyridine complex, 12.5percent HCl; 2.) aq. NaOH / 1.) methanol, ice-water bath, 25 min, then 4h, then 20-30 min; 2.) 1h

4: 12 percent / polyphosphoric acid / 1 h / 85 °C

With hydrogenchloride; sodium hydroxide; PPA; borane pyridine; hydrogen; palladium on activated charcoal; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)98949-5