<3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole

Base Information

• Chemical Name: <3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole
• CAS No.: 133116-06-0
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.321

Synonyms:

Chemical Property of <3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of <3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole

There total 17 articles about <3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol (69423-36-5) → <3S*,4α,5α>-3a,5,6,6a-tetrahydro-3-(anti-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole (133116-06-0,133163-76-5,133163-77-6,133163-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA, hexamethylphosphoric triamide / 1) THF, -80 deg C, 20 h, 2) -80 deg C, 1 h

2: 1) LDEA, hexamethylphosphoric triamide / 1) THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1016/S0040-4020(01)89051-7

Reference yield:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol (69423-36-5) → <3S*,4α,5α>-3a,5,6,6a-tetrahydro-3-(syn-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole (133116-06-0,133163-76-5,133163-77-6,133163-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA, hexamethylphosphoric triamide / 1) THF, -80 deg C, 20 h, 2) -80 deg C, 1 h

2: 1) LDEA, hexamethylphosphoric triamide / 1) THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1016/S0040-4020(01)89051-7

Reference yield:

3-Methyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol (69423-36-5) → <3R*,4α,5α>-3a,5,6,6a-tetrahydro-3-(syn-2-hydroxy-1-methyl-2-phenyl-ethyl)-4H-cyclopentisoxazole (133116-06-0,133163-76-5,133163-77-6,133163-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA, hexamethylphosphoric triamide / 1) THF, -80 deg C, 20 h, 2) -80 deg C, 1 h

2: 1) LDEA, hexamethylphosphoric triamide / 1) THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1016/S0040-4020(01)89051-7

upstream raw materials:

3-Ethyl-4,5,6,6a-tetrahydro-3aH-cyclopentisoxazol

benzaldehyde

<3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(2-hydroxy-2-phenylethyl)-4H-cyclopentisoxazole

methyl iodide

Downstream raw materials:

<3R^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(1-methyl-2-phenylethyl)-4H-cyclopentisoxazole

Dithiocarbonic acid S-methyl ester O-((1R,2R)-1-phenyl-2-(3aS,6aS)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazol-3-yl-propyl) ester

Dithiocarbonic acid S-methyl ester O-((1S,2R)-1-phenyl-2-(3aS,6aS)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazol-3-yl-propyl) ester

<3S^*,4α,5α>-3a,5,6,6a-tetrahydro-3-(1-methyl-2-phenylethyl)-4H-cyclopentisoxazole

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