N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide

Base Information

• Chemical Name: N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide
• CAS No.: 1351438-40-8
• Molecular Formula: C₁₅H₁₅NS
• Molecular Weight: 242.349
• Mol file: 1351438-40-8.mol

Synonyms:

Chemical Property of N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide

There total 4 articles about N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,5-dimethyl-N-(phenyl-2-d)benzamide (1351438-42-0) → N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide (1351438-40-8)

Guidance literature:

With Lawesson's reagent; In toluene; at 120 ℃; for 3h; Kinetics; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.5b05665

Reference yield:

3,5-dimethylbenzoyl chloride (6613-44-1) + 2-bromoaniline (615-36-1) → C15H15NS + N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide (1351438-40-8)

Guidance literature:

2-bromoaniline; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With water-d2; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

3,5-dimethylbenzoyl chloride; Further stages;

DOI:10.1039/c1cc16184a

Reference yield:

3,5-dimethylbenzoyl chloride (6613-44-1) → N-(2-deuterium phenyl)-3,5-dimethylbenzothiozamide (1351438-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: Lawessons reagent / toluene / 2 h / Reflux; Inert atmosphere

With Lawessons reagent; triethylamine; In dichloromethane; toluene;

DOI:10.1021/acs.orglett.1c01571

upstream raw materials:

3,5-dimethylbenzoyl chloride

2-bromoaniline

3,5-dimethyl-N-(phenyl-2-d)benzamide

2-deuterioaniline