methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

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Chemical Name:methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate
CAS No.:1352391-62-8
Molecular Formula:C₄₅H₅₂N₈O₆
Molecular Weight:800.958
Hs Code.:

methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

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Chemical Property of methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

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Technology Process of methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

There total 7 articles about methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 1352391-62-8
methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 3 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

3.2: pH 3

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 2 h / 100 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

8.2: 2 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; sodium hexamethyldisilazane; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; xylene;

Reference yield:

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1352391-62-8
methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 2 h / 100 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

6.2: 2 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; xylene;

Reference yield:

: 462125-00-4
(S)-4-trifluoromethanesulfonyloxy-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1352391-62-8
methyl N-[(2S)-1-[(2S)-2-{5-[6-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]-4-methyl-2,5-dihydro-1H-pyrrol-2-yl]-1H-imidazol-5-yl}phenyl)naphthalen-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]3-methyl-1-oxobutan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 95 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; dimethyl sulfoxide / 2 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

7.2: 2 h / 20 °C

With lithium hydroxide monohydrate; ammonium acetate; water; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; xylene;