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Base Information Edit
  • Chemical Name:(3R,4S)-1-(4-fluorophenyl)-3-[(E)-3-(4-fluorophenyl)prop-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one
  • CAS No.:204589-68-4
  • Molecular Formula:C24H19F2NO2
  • Molecular Weight:391.417
  • Hs Code.:
  • DSSTox Substance ID:DTXSID601112563
  • Nikkaji Number:J1.368.525H
  • ChEMBL ID:CHEMBL367902
  • Mol file:204589-68-4.mol


Suppliers and Price of (3R,4S)-1-(4-fluorophenyl)-3-[(E)-3-(4-fluorophenyl)prop-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 3’-AnhydroEzetimibe
  • 10mg
  • $ 880.00
Total 4 raw suppliers
Chemical Property of (3R,4S)-1-(4-fluorophenyl)-3-[(E)-3-(4-fluorophenyl)prop-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one Edit
Chemical Property:
  • Melting Point:177-179°C 
  • Boiling Point:625.7±55.0 °C(Predicted) 
  • PKA:9.72±0.30(Predicted) 
  • Density:1.303±0.06 g/cm3(Predicted) 
  • Storage Temp.:Amber Vial, -20°C Freezer 
  • Solubility.:Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated 
  • XLogP3:5
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:5
  • Exact Mass:391.13838517
  • Heavy Atom Count:29
  • Complexity:573

98% *data from raw suppliers

3’-AnhydroEzetimibe *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
  • Canonical SMILES:C1=CC(=CC=C1C=CCC2C(N(C2=O)C3=CC=C(C=C3)F)C4=CC=C(C=C4)O)F
  • Isomeric SMILES:C1=CC(=CC=C1/C=C/C[C@@H]2[C@H](N(C2=O)C3=CC=C(C=C3)F)C4=CC=C(C=C4)O)F
  • Uses 3’-Anhydro Ezetimibe is a metabolite of Ezetimibe (E975000), an antihyperlipoproteinemic which is a cholesterol absorption inhibitor.
Technology Process of (3R,4S)-1-(4-fluorophenyl)-3-[(E)-3-(4-fluorophenyl)prop-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one

There total 11 articles about (3R,4S)-1-(4-fluorophenyl)-3-[(E)-3-(4-fluorophenyl)prop-2-enyl]-4-(4-hydroxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 5 steps
1: oxalyl chloride / CH2Cl2 / 16 h / 22 °C
2: (Ph3P)4Pd / tetrahydrofuran / 1 h / 10 °C
3: BH3*Me2S / tetrahydrofuran / 3 h / 22 °C
4: H2 / 10percent Pd/C / ethanol / 16 h / 3102.9 Torr
5: p-TsOH*H2O / toluene / 6 h / 80 °C
With tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; dimethylsulfide borane complex; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene;
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