methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

Base Information

• Chemical Name: methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside
• CAS No.: 134407-39-9
• Molecular Formula: C₄₉H₅₈N₆O₁₂
• Molecular Weight: 923.033
• Mol file: 134407-39-9.mol

Synonyms:

Chemical Property of methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

There total 6 articles about methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-di-O-acetyl-3,4-di-O-benzyl-6-deoxy-α-D-mannopyranose (134524-12-2) → methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside (134407-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / boron trifluoride etherate, molecular sieves (4 Angstroem) / CH₂Cl₂ / 8 h / Ambient temperature

2: 1.) Br₂, cyclohexene, 2.) mercuric cyanide, mercuric bromide, molecular sieves (4 Angstroem) / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, a) 0 deg C, 4 h, b.) 16 h

3: 1.) molecular sieves (4Angstroem), 2.) silver triflate, Br₂, Et₃N / 1.) CH₂Cl₂, 4 h, r.t., 2.) 60 min, r.t.

With 4 A molecular sieve; boron trifluoride diethyl etherate; bromine; silver trifluoromethanesulfonate; mercury(II) cyanide; triethylamine; mercury dibromide; cyclohexene; In dichloromethane;

DOI:10.1016/0008-6215(91)84146-6

Reference yield:

(2S,3S,4S,5S,6R)-5-azidotetrahydro-2-methoxy-6-methyl-2H-pyran-3,4-diol (20881-80-5) → methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside (134407-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) dibutyltin oxide, 2.) tetrabutylammonium chloride / 1.) CH₃OH, 2 h, reflux, 2.) toluene, 1 h, reflux

2: 1.) molecular sieves (4Angstroem), 2.) silver triflate, Br₂, Et₃N / 1.) CH₂Cl₂, 4 h, r.t., 2.) 60 min, r.t.

With 4 A molecular sieve; tetrabutyl-ammonium chloride; bromine; silver trifluoromethanesulfonate; di(n-butyl)tin oxide; triethylamine;

DOI:10.1016/0008-6215(91)84146-6

Reference yield:

benzyl bromide (100-39-0) → methyl O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-(1->2)-O-(4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranosyl)-(1->2)-4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside (134407-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) dibutyltin oxide, 2.) tetrabutylammonium chloride / 1.) CH₃OH, 2 h, reflux, 2.) toluene, 1 h, reflux

2: 1.) molecular sieves (4Angstroem), 2.) silver triflate, Br₂, Et₃N / 1.) CH₂Cl₂, 4 h, r.t., 2.) 60 min, r.t.

With 4 A molecular sieve; tetrabutyl-ammonium chloride; bromine; silver trifluoromethanesulfonate; di(n-butyl)tin oxide; triethylamine;

DOI:10.1016/0008-6215(91)84146-6

upstream raw materials:

methyl 4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

ethyl 2-O-(2-O-acetyl-3,4-di-O-benzyl-α-D-rhamnopyranosyl)-4-azido-3-O-benzyl-4,6-dideoxy-1-thio-α-D-mannopyranoside

(2S,3S,4S,5S,6R)-5-azidotetrahydro-2-methoxy-6-methyl-2H-pyran-3,4-diol

benzyl bromide