Technology Process of (2S,5R,6R)-6-Carbamoylmethyl-3,3-dimethyl-4,7-dioxo-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester
There total 4 articles about (2S,5R,6R)-6-Carbamoylmethyl-3,3-dimethyl-4,7-dioxo-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzyltrimethylammonium chloride; magnesium monoperoxyphthalate hexahydrate;
In
chloroform;
for 5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 4 Angstroem molecular sieves, DBU / CH2Cl2 / 1.) -78 deg C, 2.) -78 deg C, 1.5 h; -78 deg C to 20 deg C, 1 h
2: tetrahydrofuran / 1.5 h / Ambient temperature
3: 33 percent / acetic acid, potassium azodicarboxylate / tetrahydrofuran; acetone / 48 h / Ambient temperature
4: 55 percent / 80percent aq. magnesium monoperoxyphthalate hexahydrate, benzyltrimethylammonium chloride / CHCl3 / 5 h / Ambient temperature
With
4 A molecular sieve; potassium diazodicarboxylate; benzyltrimethylammonium chloride; magnesium monoperoxyphthalate hexahydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dichloromethane; chloroform; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran / 1.5 h / Ambient temperature
2: 33 percent / acetic acid, potassium azodicarboxylate / tetrahydrofuran; acetone / 48 h / Ambient temperature
3: 55 percent / 80percent aq. magnesium monoperoxyphthalate hexahydrate, benzyltrimethylammonium chloride / CHCl3 / 5 h / Ambient temperature
With
potassium diazodicarboxylate; benzyltrimethylammonium chloride; magnesium monoperoxyphthalate hexahydrate; acetic acid;
In
tetrahydrofuran; chloroform; acetone;
![(2S,5R)-6-Carbamoylmethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
