Technology Process of (3R,5S)-3,5-Bis-benzyloxy-6-oxo-hexanoic acid methyl ester
There total 8 articles about (3R,5S)-3,5-Bis-benzyloxy-6-oxo-hexanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - -45 ℃;
Yield given;
DOI:10.1016/S0957-4166(96)00525-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH, pyridine, 2.) TBDMSCl, 3.) NaH, nBu4NI, 4.) TBAF, 5.) PCC/Celite, AcONa
2: lithium (S,S')-α,α'-dimethyldibenzylamide / tetrahydrofuran / -100 °C
3: 1.) O3, 2.) PPh3 / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
4: NaBH4 / methanol / Ambient temperature
5: K2CO3 / dimethylformamide / Ambient temperature
6: (COCl)2, DMSO, Et3N / CH2Cl2 / -78 - -45 °C
With
pyridine; sodium tetrahydroborate; oxalyl dichloride; Celite; tetrabutyl ammonium fluoride; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; lithium (S,S)-bis(α-methylbenzyl)amide; ozone; tert-butyldimethylsilyl chloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(96)00525-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: PCC/Celite, AcONa / CH2Cl2 / Ambient temperature
2: lithium (S,S')-α,α'-dimethyldibenzylamide / tetrahydrofuran / -100 °C
3: 1.) O3, 2.) PPh3 / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
4: NaBH4 / methanol / Ambient temperature
5: K2CO3 / dimethylformamide / Ambient temperature
6: (COCl)2, DMSO, Et3N / CH2Cl2 / -78 - -45 °C
With
sodium tetrahydroborate; oxalyl dichloride; Celite; sodium acetate; potassium carbonate; lithium (S,S)-bis(α-methylbenzyl)amide; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(96)00525-3
