2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide

Base Information

• Chemical Name: 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide
• CAS No.: 1428732-54-0
• Molecular Formula: BrH*C₂₀H₃₄NOP
• Molecular Weight: 416.382
• Mol file: 1428732-54-0.mol

Synonyms:

Chemical Property of 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide

There total 3 articles about 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethyl-2-(hydroxymethyl)benzamide (103258-38-4) → 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide (1428732-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus tribromide / dichloromethane / 3 h / 0 °C

2: acetone / Schlenk technique; Inert atmosphere; Reflux

With phosphorus tribromide; In dichloromethane; acetone;

DOI:10.1039/c3ob40198g

Reference yield:

2-benzofuran-1(3H)-one (87-41-2) → 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide (1428732-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.5 h / 20 °C

1.2: 0.83 h / 20 °C

2.1: phosphorus tribromide / dichloromethane / 3 h / 0 °C

3.1: acetone / Schlenk technique; Inert atmosphere; Reflux

With aluminum (III) chloride; phosphorus tribromide; In dichloromethane; 1,2-dichloro-ethane; acetone;

DOI:10.1039/c3ob40198g

Reference yield:

di-tert-butylphosphine (819-19-2) + N,N-diethyl-2-(bromomethyl)benzamide (103258-32-8) → 2-((di-tert-butylphosphino)methyl)-N,N-diethybenzamide hydrobromide (1428732-54-0)

Guidance literature:

In acetone; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1039/c3ob40198g

upstream raw materials:

N,N-diethyl-2-(hydroxymethyl)benzamide

di-tert-butylphosphine

N,N-diethyl-2-(bromomethyl)benzamide

2-benzofuran-1(3H)-one