Technology Process of 1,4,7-tris(2-hydroxy-5-methyl-3-neopentylbenzyl)-1,4,7-triazacyclononane
There total 3 articles about 1,4,7-tris(2-hydroxy-5-methyl-3-neopentylbenzyl)-1,4,7-triazacyclononane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; 1,4,7-triazacyclononane;
In
methanol;
for 2h;
Reflux;
Inert atmosphere;
4-methyl-2-neopentylphenol;
In
methanol;
for 60h;
Reflux;
Inert atmosphere;
DOI:10.1039/c2cc34150f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 5 h / -35 - 20 °C / Inert atmosphere
1.2: 7 h / -60 - 20 °C / Inert atmosphere
2.1: hydrazine / diethylene glycol / 20 h / Reflux; Inert atmosphere
3.1: potassium hydroxide / diethylene glycol / 3 h / 190 - 205 °C / Reflux
3.2: 4 h / 200 - 205 °C / Reflux; Inert atmosphere
4.1: boron tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere
5.1: methanol / 2 h / Reflux; Inert atmosphere
5.2: 60 h / Reflux; Inert atmosphere
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; boron tribromide; potassium hydroxide; hydrazine;
In
methanol; diethyl ether; hexane; dichloromethane; diethylene glycol;
2.1: Wolff-Kishner reduction / 5.1: Mannich reaction / 5.2: Mannich reaction;
DOI:10.1039/c2cc34150f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / diethylene glycol / 3 h / 190 - 205 °C / Reflux
1.2: 4 h / 200 - 205 °C / Reflux; Inert atmosphere
2.1: boron tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere
3.1: methanol / 2 h / Reflux; Inert atmosphere
3.2: 60 h / Reflux; Inert atmosphere
With
boron tribromide; potassium hydroxide;
In
methanol; dichloromethane; diethylene glycol;
3.1: Mannich reaction / 3.2: Mannich reaction;
DOI:10.1039/c2cc34150f
