C₂₇H₃₆ClN₅O₃

Base Information

• Chemical Name: C₂₇H₃₆ClN₅O₃
• CAS No.: 1396256-36-2
• Molecular Formula: C₂₇H₃₆ClN₅O₃
• Molecular Weight: 514.068
• Mol file: 1396256-36-2.mol

Synonyms:

Chemical Property of C₂₇H₃₆ClN₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₆ClN₅O₃

There total 17 articles about C₂₇H₃₆ClN₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H34ClN5O3 → C27H36ClN5O3 (1396256-36-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 13h;

DOI:10.1021/jm301024w

Reference yield:

tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)carbamate (1001270-26-3) → C27H36ClN5O3 (1396256-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: sodium carbonate

2.2: 0.08 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 13 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; sodium carbonate; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1021/jm301024w

Reference yield:

(R)-4-benzyl-3-(2-(4-chlorophenyl)acetyl)oxazolidin-2-one (220041-96-3) → C27H36ClN5O3 (1396256-36-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane; toluene / 0.25 h / -78 °C

1.2: 1.75 h / -78 - 20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; dichloromethane / 19 h / 20 °C

3.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 12.42 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 4 h / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: sodium carbonate

6.2: 0.08 h / 20 °C

7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 13 h / 20 °C

With hydrogenchloride; water; dihydrogen peroxide; titanium tetrachloride; sodium tris(acetoxy)borohydride; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.2: |Mannich Aminomethylation;

DOI:10.1021/jm301024w

upstream raw materials:

(R)-tert-butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]-pyrimidin-4-yl)piperazine-1-carboxylate

tert-butyl 4-((5R,7R)-5-methyl-7-((4-nitrobenzoyl)oxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-piperazine-1-carboxylate

tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)carbamate

(R)-4-benzyl-3-(2-(4-chlorophenyl)acetyl)oxazolidin-2-one

Refernces