α-phenyltropolone

Base Information

• Chemical Name: α-phenyltropolone
• CAS No.: 56968-74-2
• Molecular Formula: C₁₃H₁₀O₂
• Molecular Weight: 198.221
• Mol file: 56968-74-2.mol

Synonyms:

Chemical Property of α-phenyltropolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-phenyltropolone

There total 15 articles about α-phenyltropolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-amino-2-phenyltropone (16446-76-7) → α-phenyltropolone (56968-74-2,341033-14-5)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 100 ℃; for 12h;

DOI:10.1002/chem.201902702

Reference yield: 86.0%

2-methoxy-7-phenylcyclohepta-2,4,6-trien-1-one (115436-59-4) → α-phenyltropolone (56968-74-2,341033-14-5)

Guidance literature:

With hydrogenchloride; In methanol; for 6h; Heating;

DOI:10.1021/jm9701942

Reference yield:

2-chlorotropone (3839-48-3) → α-phenyltropolone (56968-74-2,341033-14-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 16 h / 75 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 20 °C / Inert atmosphere

3: potassium hydroxide / water; ethanol / 16 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; ethanol; water; 1: |Suzuki Coupling;

DOI:10.1021/ml400158k

upstream raw materials:

2-bromo-7-phenyl-cycloheptatrienone

5-bromo-3-phenyl-tropolone

7-amino-2-phenyltropone

3-bromo-7-phenyl-tropolone

Downstream raw materials:

2-amino-4-phenylazulene-1,3-dicarbonitrile

2-methoxy-7-phenylcyclohepta-2,4,6-trien-1-one

2-methoxy-3-phenylcyclohepta-2,4,6-trien-1-one

Acetic acid 6-acetoxy-7-oxo-2-phenyl-cyclohepta-1,3,5-trienyl ester