16446-76-7

Upstream product

• 14562-09-5 2-phenylcyclohepta-2,4,6-triene-1-one 
• 115436-59-4 2-methoxy-7-phenylcyclohepta-2,4,6-trien-1-one 
• 2161-40-2 2-methoxytropone 
• 56968-74-2 3-phenyl-tropolone 
• 98-80-6 phenylboronic acid 
• 3839-48-3 2-chlorotropone 
• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 

Downstream Products

• 56968-74-2 3-phenyl-tropolone 
• 100397-97-5 7-amino-4-bromo-2-phenyl-cycloheptatrienone 
• 107624-86-2 2-amino-3-phenyl-cycloheptatrienone 
• 115436-59-4 2-methoxy-7-phenylcyclohepta-2,4,6-trien-1-one 
• 107412-72-6 2-methoxy-3-phenylcyclohepta-2,4,6-trien-1-one 
• 107518-20-7 2-hydrazino-7-phenyl-cycloheptatrienone 
• 875243-02-0 5-nitro-3-phenyl-tropolone 
• 56968-74-2 α-phenyltropolone 
• 93819-34-2 2-amino-4-phenylazulene-1,3-dicarbonitrile 

Relevant academic research and scientific papers

The Effect of Base and Nucleophile on the Nucleophilic Substitution of Methoxytropone Derivatives: An Easy Access to 4- And 5-Substituted Multifunctional Azulenes

The nucleophilic substitution on 3-substituted 2-methoxytropones to form azulenes is dependent on the nucleophile and base employed. With bulkier nucleophiles (ethyl/methyl cyanoacetate), the reaction proceeds with the abnormal nucleophilic substitution i

Abnormal Nucleophilic Substitution on Methoxytropone Derivatives: Steric Strategy to Synthesize 5-Substituted Azulenes

Azulene is a non-alternant non-benzenoid aromatic system, and in turn, it possesses unusual photophysical properties. Azulene-based conjugated systems have received increasing interest in recent years as optoelectronic materials. Despite the routes availa

Tropolones as lead-like natural products: The development of potent and selective histone deacetylase inhibitors

Natural products have long been recognized as a rich source of potent therapeutics but further development is often limited by high structural complexity and high molecular weight. In contrast, at the core of the thujaplicins is a lead-like tropolone scaf

SUBSTITUTED TROPOLONE DERIVATIVES AND METHODS OF USE

The compositions and methods described herein relate generally to substituted tropolone derivatives, which, among other features, are useful as histone deacetylase (HDAC) inhibitors.