(R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

Base Information

Chemical Name:(R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran
CAS No.:1370450-45-5
Molecular Formula:C₂₄H₂₈O
Molecular Weight:332.486
Hs Code.:

Synonyms:

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Chemical Property of (R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

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Technology Process of (R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

There total 3 articles about (R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370450-37-5
(R)-(Z)-2-bromo-5-ethyl-3-methyl-1-phenylhept-1-en-3-ol

: 1370450-45-5
(R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; water; bis-triphenylphosphine-palladium(II) chloride / 80 °C

2: potassium tert-butylate / dimethyl sulfoxide / 1 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; water; triethylamine; In dimethyl sulfoxide; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201301476

Reference yield:

: 22965-96-4
(Z)-3-bromo-4-phenyl-3-buten-2-one

: 1370450-45-5
(R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide dimethylsulfide complex; (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine / tert-butyl methyl ether; diethyl ether / -78 °C / Inert atmosphere; Schlenk technique

2: triethylamine; copper(l) iodide; water; bis-triphenylphosphine-palladium(II) chloride / 80 °C

3: potassium tert-butylate / dimethyl sulfoxide / 1 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(I) bromide dimethylsulfide complex; (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine; potassium tert-butylate; water; triethylamine; In diethyl ether; tert-butyl methyl ether; dimethyl sulfoxide; 1: |Grignard Reaction / 2: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201301476

Reference yield:

: 68506-84-3
(2-ethylbutyl)magnesium bromide

: 1370450-45-5
(R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide dimethylsulfide complex; (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine / tert-butyl methyl ether; diethyl ether / -78 °C / Inert atmosphere; Schlenk technique

2: triethylamine; copper(l) iodide; water; bis-triphenylphosphine-palladium(II) chloride / 80 °C

3: potassium tert-butylate / dimethyl sulfoxide / 1 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(I) bromide dimethylsulfide complex; (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine; potassium tert-butylate; water; triethylamine; In diethyl ether; tert-butyl methyl ether; dimethyl sulfoxide; 1: |Grignard Reaction / 2: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201301476