68506-84-3

Usage

InChI:InChI=1/C6H13.BrH.Mg/c1-4-6(3)5-2;;/h6H,3-5H2,1-2H3;1H;/q;;+1/p-1/rC6H13BrMg/c1-3-6(4-2)5-8-7/h6H,3-5H2,1-2H3

Upstream product

• 3814-34-4 2-ethyl-1-bromobutane 
• 7439-95-4 magnesium 

Downstream Products

• 913708-51-7 4-ethyl-2-(2-hydroxy-1-phenyl-ethylamino)-2-methyl-hexanoic acid 
• 909024-76-6 (3S,5S)-3-(2-ethylbutyl)-3-methyl-5-phenylmorpholin-2-one 
• 1608153-91-8 (R)-(E)-3-allyloxy-5-ethyl-3-methyl-1-phenylhept-1-ene 
• 1608153-88-3 (R)-(E)-5-ethyl-3-methyl-1-phenylhept-1-en-3-ol 
• 1370450-45-5 (R)-3-[(E)-benzylidene]-2-(2-ethylbutyl)-2-methyl-5-phenyl-2,3-dihydrofuran 
• 1370450-44-4 (R)-3-[(E)-benzylidene]-6-ethyl-4-methyl-1-phenyloct-1-yn-4-ol 
• 1442467-11-9 (Z)-2-bromo-5-ethyl-3-methyl-1-phenylhept-1-en-3-ol 
• 1370450-37-5 (R)-(Z)-2-bromo-5-ethyl-3-methyl-1-phenylhept-1-en-3-ol 
• 1379663-91-8 (+)-(R)-4-ethyl-2-(m-tolyl)hexan-2-ol 
• 1379663-89-4 (+)-(R)-4-ethyl-2-(3-methoxyphenyl)hexan-2-ol 

Relevant academic research and scientific papers

MODIFIED AMINE LIPIDS

The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT

A novel pyrimidine nucleoside compound represented by the following formula (1) : (wherein one of X and Y represents a cyano group, and the other represents a hydrogen atom; one of R1 and R2 represents a hydrogen atom, a carbonyl group having a C1-C6 alkyl group which has been mono-substituted by an amino group, or a group represented by (R3) (R4) (R5) Si-, and the other represents a silyl group represented by (R6) (R7) (R8) Si-, or R1 and R2 together form a 6-membered cyclic group represented by -Si(R9)(R10)-; R3, R4, R5, R6, R7, and R8 each represent an alkyl group, a cyclic alkyl group, an aryl group, or an alkyl group which has been substituted by one or two aryl groups; and R9 and R10 each represent an alkyl group) or a salt thereof. The novel pyrimidine nucleoside compound exhibits excellent anti-tumor effect as compared with existing pyrimidine nucleoside compounds.

Amino acid derivatives

The present invention relates to a method of treating pain using a compound of formula wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to certain novel derivatives of formula (I).

Therapeutic agents

Compounds of formula I STR1 in which n=0 or 1; in which, when n=0, R1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n=1, R1 is H or an alkyl group; in which R2 and R3 are H or an alkyl group; in which A is a group of formula III in which W is an oxygen atom or a group of formula --S(O)m --, a group of formula --CR12 R13 --, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5. in which R4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula --OR20, --SR20, --SOR20 or SO2 R20. in which R5, R6 and R7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R5 and R6, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring; in which R8 and R9 are H or an alkyl group containing 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.