Technology Process of 2-[2-(1,2-Dimethyl-6-oxo-cyclohexyl)-ethyl]-malonic acid dimethyl ester
There total 7 articles about 2-[2-(1,2-Dimethyl-6-oxo-cyclohexyl)-ethyl]-malonic acid dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / Hg(OAc)2 / 120 h
2: 82 percent / 11 h / 200 °C
3: 72 percent / ammonium acetate, acetic acid / benzene / Heating; 1.) 2.5 h, 2.) 3 h
4: 96 percent / cuprous bromide, 3.5 M Red-Al, anhydrous 2-butanol / tetrahydrofuran; benzene / 2 h / -20 °C
5: 1.) O3, 2.) acetic acid, Zn / 1.) CH2Cl2, methanol, 10 min, -78 deg C; 2.) -78 deg C to RT
With
mercury(II) diacetate; ozone; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; copper(I) bromide; zinc;
ammonium acetate; acetic acid;
In
tetrahydrofuran; benzene;
DOI:10.1016/S0040-4020(01)87738-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) 1 M diisobutylaluminium hydride, 2.) Rochelle salt / 1.) hexane, petroleum ether, -78 deg C, 3 h, 2.) -78 deg C to RT
2: 82 percent / Hg(OAc)2 / 120 h
3: 82 percent / 11 h / 200 °C
4: 72 percent / ammonium acetate, acetic acid / benzene / Heating; 1.) 2.5 h, 2.) 3 h
5: 96 percent / cuprous bromide, 3.5 M Red-Al, anhydrous 2-butanol / tetrahydrofuran; benzene / 2 h / -20 °C
6: 1.) O3, 2.) acetic acid, Zn / 1.) CH2Cl2, methanol, 10 min, -78 deg C; 2.) -78 deg C to RT
With
mercury(II) diacetate; diisobutylaluminium hydride; ozone; acetic acid; rochelle salt; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; copper(I) bromide; zinc;
ammonium acetate; acetic acid;
In
tetrahydrofuran; benzene;
DOI:10.1016/S0040-4020(01)87738-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / 11 h / 200 °C
2: 72 percent / ammonium acetate, acetic acid / benzene / Heating; 1.) 2.5 h, 2.) 3 h
3: 96 percent / cuprous bromide, 3.5 M Red-Al, anhydrous 2-butanol / tetrahydrofuran; benzene / 2 h / -20 °C
4: 1.) O3, 2.) acetic acid, Zn / 1.) CH2Cl2, methanol, 10 min, -78 deg C; 2.) -78 deg C to RT
With
ozone; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; iso-butanol; copper(I) bromide; zinc;
ammonium acetate; acetic acid;
In
tetrahydrofuran; benzene;
DOI:10.1016/S0040-4020(01)87738-3
