6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Base Information

Chemical Name:6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid
CAS No.:1613717-39-7
Molecular Formula:C₂HF₃O₂*C₂₃H₂₇N₅O₂
Molecular Weight:519.524
Hs Code.:

6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Synonyms:

Suppliers and Price of 6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

There total 9 articles about 6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1613717-02-4
6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

: 1613717-39-7
6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

: 6-[(1,3-dimethyl-azetidin-3-yl)methyamino]-4(S)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: With chiralpak AD; In methanol; Resolution of racemate;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-05-3
(R)-2-(6-nitro-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613717-39-7
6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

: 6-[(1,3-dimethyl-azetidin-3-yl)methyamino]-4(S)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrazine hydrate / ethanol / 16 h / 20 °C

2.1: ammonium chloride; zinc / methanol; tetrahydrofuran / 16 h / 50 °C

3.1: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

4.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

5.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C

6.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol; tetrahydrofuran; water / 4 h / 50 °C / 2585.81 Torr

7.1: acetic acid / methanol / 20 °C

7.2: 20 °C

8.1: chiralpak AD / methanol / Resolution of racemate

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; ammonium chloride; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; isopropyl alcohol; 5.1: |Suzuki Coupling;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-06-4
(R)-4-methyl-6-nitro-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 1613717-39-7
6-[(1,3-dimethylazetidin-3-yl)methylamino]-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

: 6-[(1,3-dimethyl-azetidin-3-yl)methyamino]-4(S)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; zinc / methanol; tetrahydrofuran / 16 h / 50 °C

2.1: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

3.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

4.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C

5.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol; tetrahydrofuran; water / 4 h / 50 °C / 2585.81 Torr

6.1: acetic acid / methanol / 20 °C

6.2: 20 °C

7.1: chiralpak AD / methanol / Resolution of racemate

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; 4.1: |Suzuki Coupling;
DOI:10.1021/jm5013006