6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

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Chemical Name:6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid
CAS No.:1613717-02-4
Molecular Formula:C₂HF₃O₂*C₂₃H₂₇N₅O₂
Molecular Weight:519.524
Hs Code.:

Synonyms:6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

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Chemical Property of 6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

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Technology Process of 6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

There total 8 articles about 6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (R)-4-methyl-6-(3-methylazetidin-3-ylamino)-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one

: 76-05-1
trifluoroacetic acid

: 1613717-02-4
6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: formaldehyd; (R)-4-methyl-6-(3-methylazetidin-3-ylamino)-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one; With acetic acid; In methanol; at 20 ℃;

With sodium cyanoborohydride; In methanol; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-04-2
(R)-2-(6-nitro-3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613717-02-4
6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: Lawessons reagent / toluene / 3 h / 120 °C

2.1: hydrazine hydrate / ethanol / 16 h / 20 °C

3.1: ammonium chloride; zinc / methanol; tetrahydrofuran / 16 h / 50 °C

4.1: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

5.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C

7.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol; tetrahydrofuran; water / 4 h / 50 °C / 2585.81 Torr

8.1: acetic acid / methanol / 20 °C

8.2: 20 °C

With Lawessons reagent; hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; ammonium chloride; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; isopropyl alcohol; toluene; 6.1: |Suzuki Coupling;
DOI:10.1021/jm5013006

Reference yield:

: 1613721-05-3
(R)-2-(6-nitro-3-thioxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propionic acid ethyl ester

: 1613717-02-4
6-[(1,3-dimethyl-azetidin-3-yl)methylamino]-4-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine hydrate / ethanol / 16 h / 20 °C

2.1: ammonium chloride; zinc / methanol; tetrahydrofuran / 16 h / 50 °C

3.1: potassium carbonate / isopropyl alcohol / 16 h / 80 - 90 °C

4.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 0.5 h / 20 °C

5.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C

6.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol; tetrahydrofuran; water / 4 h / 50 °C / 2585.81 Torr

7.1: acetic acid / methanol / 20 °C

7.2: 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; ammonium chloride; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; isopropyl alcohol; 5.1: |Suzuki Coupling;
DOI:10.1021/jm5013006