2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-
• CAS No.: 137473-27-9
• Molecular Formula: C12H14O4S
• Molecular Weight: 254.307
• Hs Code.: 2916399090
• Mol file: 137473-27-9.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-

Chemical Property:

• PSA: 68.82000
• LogP: 2.74720

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-methanesulfonylcinnamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-

There total 9 articles about 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4‐methoxy‐N‐(4‐(methylsulfonyl)benzylidene)aniline (197905-49-0) + (benzothiazole-2-sulfonyl)-acetic acid ethyl ester (24045-02-1) → ethyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate (137473-27-9)

Guidance literature:

In tetrahydrofuran; at 70 ℃; for 40h; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201101684

Reference yield: 92.0%

ethanol (64-17-5) + 3-(4-methanesulfonyl-phenyl)-acrylic acid (5345-30-2,88899-85-8) → ethyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate (137473-27-9)

Guidance literature:

With thionyl chloride; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1055/s-0031-1289706

Reference yield: 65.0%

1-(methylsulfonyl)-4-vinyl-benzene (97410-25-8) + ethylhydrazine carboxylate (4114-31-2) → ethyl (2E)-3-[4-(methylsulfonyl)phenyl]acrylate (137473-27-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); oxygen; copper(l) chloride; In acetonitrile; at 70 ℃; for 5h; under 760.051 Torr; regioselective reaction; Schlenk technique; Molecular sieve;

DOI:10.1039/c3cc42994f

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

para-methanesulfonylbenzaldehyde

ethanol

3-(4-methanesulfonyl-phenyl)-acrylic acid

Downstream raw materials:

(E)-3-[4-(methylsulfonyl)phenyl]prop-2-en-1-ol

ethyl (2R,3S)-2,3-dihydroxy-3-[4-(methylsulfonyl)phenyl]propanoate

ethyl (2R,3S)-3-hydroxy-3-[4-(methylsulfonyl)phenyl]-2-{[(4-nitrophenyl)sulfonyl]oxy}propanoate

3-(4-methanesulfonyl-phenyl)-acrylic acid