2-phenyl-3-vinylbenzofuran

Base Information

• Chemical Name: 2-phenyl-3-vinylbenzofuran
• CAS No.: 211803-93-9
• Molecular Formula: C₁₆H₁₂O
• Molecular Weight: 220.271
• Mol file: 211803-93-9.mol

Synonyms:

Chemical Property of 2-phenyl-3-vinylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3-vinylbenzofuran

There total 3 articles about 2-phenyl-3-vinylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

(E)-2-(2-nitroprop-1-en-1-yl) phenol (86029-73-4) + benzoyl chloride (98-88-4) → 2-phenyl-3-vinylbenzofuran (211803-93-9)

Guidance literature:

With phenylsilane; triethylamine; 3-Methyl-1-phenyl-2-phospholene 1-oxide; In m-xylene; at 100 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c00737

Reference yield: 16.0%

1-(phenylethynyl)-2-(vinyloxy)-benzene (1393481-89-4) → 2-phenyl-3-vinylbenzofuran (211803-93-9)

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; chlorobenzene; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201201186

Reference yield:

salicylaldehyde (90-02-8) → 2-phenyl-3-vinylbenzofuran (211803-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride; dimethyl amine / toluene / 12 h / 130 °C / Dean-Stark; Inert atmosphere

2: triethylamine; phenylsilane; 3-Methyl-1-phenyl-2-phospholene 1-oxide / m-xylene / 4 h / 100 °C / Inert atmosphere; Schlenk technique

With potassium fluoride; phenylsilane; dimethyl amine; triethylamine; 3-Methyl-1-phenyl-2-phospholene 1-oxide; In m-xylene; toluene;

DOI:10.1021/acs.orglett.1c00737

upstream raw materials:

1-(phenylethynyl)-2-(vinyloxy)-benzene

(E)-2-(2-nitroprop-1-en-1-yl) phenol

benzoyl chloride

salicylaldehyde