2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine

Base Information

• Chemical Name: 2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine
• CAS No.: 886758-59-4
• Molecular Formula: C₂₄H₃₃IN₄O₇
• Molecular Weight: 616.453
• Mol file: 886758-59-4.mol

Synonyms:

Chemical Property of 2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine

There total 1 articles about 2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2-methylpropanoyl)amino-6-methoxy-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine (121150-06-9) → 2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine (886758-59-4)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

DOI:10.1021/jo060300k

Reference yield: 94.0%

2-(2-methylpropanoyl)amino-6-methoxy-7-iodo-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine (886758-59-4) → 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-5-iodo-4-methoxy-4H-pyrrolo[2,3-d]pyrimidine (220036-88-4)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; for 12h;

DOI:10.1021/jo060300k

upstream raw materials:

2-(2-methylpropanoyl)amino-6-methoxy-9-[3',5'-bis-O-(2-methylpropanoyl)-β-D-2'-deoxyribofuranosyl]-7-deazapurine

Downstream raw materials:

2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-5-iodo-4-methoxy-4H-pyrrolo[2,3-d]pyrimidine