C₁₂H₈ClNO

Base Information

• Chemical Name: C₁₂H₈ClNO
• CAS No.: 1261785-72-1
• Molecular Formula: C₁₂H₈ClNO
• Molecular Weight: 217.655
• Mol file: 1261785-72-1.mol

Synonyms:

Chemical Property of C₁₂H₈ClNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₈ClNO

There total 3 articles about C₁₂H₈ClNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-phenylnicotinic acid (10177-12-5) → C12H8ClNO (1261785-72-1)

Guidance literature:

With thionyl chloride; for 4h; Reflux;

DOI:10.1016/j.bmcl.2013.05.039

Reference yield:

phenylboronic acid (98-80-6) → C12H8ClNO (1261785-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate / water; isopropyl alcohol / 7 h / 80 °C

2: thionyl chloride / 4 h / Reflux

With potassium phosphate; thionyl chloride; palladium diacetate; In water; isopropyl alcohol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.05.039

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → C12H8ClNO (1261785-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate / water; isopropyl alcohol / 7 h / 80 °C

2: thionyl chloride / 4 h / Reflux

With potassium phosphate; thionyl chloride; palladium diacetate; In water; isopropyl alcohol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.05.039

upstream raw materials:

5-bromo-3-pyridinecarboxylic acid

phenylboronic acid

5-phenylnicotinic acid

Downstream raw materials:

5-phenylnicotinic acid ethyl ester

Refernces

• 1、 Chojnacka, Kinga,Papke, Roger L.,Horenstein, Nicole A.. "Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor". . p. 4145 - 4149. Retrieved 2013/07/26.