C₁₇H₁₆F₃NO₃

Base Information

• Chemical Name: C₁₇H₁₆F₃NO₃
• CAS No.: 1440063-05-7
• Molecular Formula: C₁₇H₁₆F₃NO₃
• Molecular Weight: 339.314
• Mol file: 1440063-05-7.mol

Synonyms:

Chemical Property of C₁₇H₁₆F₃NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆F₃NO₃

There total 4 articles about C₁₇H₁₆F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H14FNO2 (1440062-33-8) + 2,6-difluorobenzoylchloride (18063-02-0) → C17H16F3NO3 (1440063-05-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 5 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3nj00032j

Reference yield:

C12H14FNO4 (1440061-63-1) → C17H16F3NO3 (1440063-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; triethylamine; In tetrahydrofuran;

DOI:10.1039/c3nj00032j

Reference yield:

C12H13FO4 (1440060-96-7) → C17H16F3NO3 (1440063-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / ethanol / 5 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

3: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; hydroxylamine hydrochloride; iodine; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1039/c3nj00032j

upstream raw materials:

C₁₂H₁₄FNO₄

C₁₂H₁₃FO₄

2-phenoxy-1-fluoroethane

C₁₀H₁₄FNO₂

Downstream raw materials:

C₁₇H₁₄F₃NO₂

C₁₇H₁₅ClF₃NO₂