2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione

Base Information

• Chemical Name: 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione
• CAS No.: 1608464-08-9
• Molecular Formula: C₄₁H₅₅N₃O₇
• Molecular Weight: 701.904
• Mol file: 1608464-08-9.mol

Synonyms:

Chemical Property of 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione

There total 13 articles about 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-3,6-dimethyl-1,4-benzoquinone (2913-45-3) → 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione (1608464-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium persulfate; silver nitrate / water; acetonitrile / 4 h / 75 °C / Darkness

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate; sodium azide / N,N-dimethyl-formamide; water / 85 °C

3: pyridinium p-toluenesulfonate / tert-butyl alcohol / 24 h / Reflux

With ammonium persulfate; sodium azide; copper(ll) sulfate pentahydrate; pyridinium p-toluenesulfonate; silver nitrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2014.03.062

Reference yield:

11-bromoundecanoic acid (2834-05-1) → 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione (1608464-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium persulfate; silver nitrate / water; acetonitrile / 4 h / 75 °C / Darkness

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate; sodium azide / N,N-dimethyl-formamide; water / 85 °C

3: pyridinium p-toluenesulfonate / tert-butyl alcohol / 24 h / Reflux

With ammonium persulfate; sodium azide; copper(ll) sulfate pentahydrate; pyridinium p-toluenesulfonate; silver nitrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2014.03.062

Reference yield:

(S)-2-((2-(benzyloxy)ethoxy)methyl)oxirane (406218-43-7) → 2-(10-(4-((S)-3-(2-((S)-3-(biphenyl-4-yl)-2-hydroxypropoxy)ethoxy)-2-hydroxypropyl)-1H-1,2,3-triazol-1-yl)decyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione (1608464-08-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: magnesium; copper(I) bromide / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 20 °C

4.1: benzyltriethylammonium chloride / 0.05 h

4.2: 22.58 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

5.2: 0.5 h / Inert atmosphere

5.3: 3 h / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / -10 °C

8.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate; sodium azide / N,N-dimethyl-formamide; water / 85 °C

9.1: pyridinium p-toluenesulfonate / tert-butyl alcohol / 24 h / Reflux

With n-butyllithium; sodium azide; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; magnesium; benzyltriethylammonium chloride; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; copper(I) bromide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2014.03.062

upstream raw materials:

11-bromoundecanoic acid

2-methoxy-3,6-dimethyl-1,4-benzoquinone

2-(10-bromodecyl)-5-methoxy-3,6-dimethylcyclohexa-2,5-diene-1,4-dione

(5S,12S)-5-(biphenyl-4-ylmethyl)-12-(prop-2-ynyl)-2,4,7,10,13,15-hexaoxahexadecane