3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxaMide

Base Information

• Chemical Name: 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxaMide
• CAS No.: 1196104-00-3
• Molecular Formula: C₉H₁₅N₃O
• Molecular Weight: 181.238
• Mol file: 1196104-00-3.mol

Synonyms:

Chemical Property of 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxaMide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-tert-Butyl-2-methyl-2H-pyrazole-3-carboxylicacidamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxaMide

There total 1 articles about 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-tert-Butyl-1-methyl-1H-pyrazole-5-carbonyl chloride (160842-62-6) → 5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid amide (1196104-00-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid amide (1196104-00-3) → 3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole (1196103-46-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 24 h / 60 °C

2.1: sodium hydride; methanol / mineral oil / 2 h / 40 °C / Inert atmosphere

2.2: 16 h / 70 °C

3.1: isopropyl alcohol / 3 h / 70 °C

With methanol; sodium hydride; trichlorophosphate; In isopropyl alcohol; mineral oil;

Reference yield:

5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid amide (1196104-00-3) → 3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-4H-[1,2,4]triazole (1196103-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 24 h / 60 °C

2.1: sodium hydride; methanol / mineral oil / 2 h / 40 °C / Inert atmosphere

2.2: 16 h / 70 °C

3.1: sodium methylate / methanol / 42 h / Reflux

With methanol; sodium methylate; sodium hydride; trichlorophosphate; In methanol; mineral oil;

upstream raw materials:

3-tert-Butyl-1-methyl-1H-pyrazole-5-carbonyl chloride

Downstream raw materials:

3-tert-butyl-5-{5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-1H-imidazol-2-yl}-1-methyl-1H-pyrazole

3-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-4H-[1,2,4]triazole

Refernces

• 1、 -. "SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR". Page/Page column 43-44. . Retrieved 2009/12/23.