C₁₂H₂₁NO₄

Base Information

• Chemical Name: C₁₂H₂₁NO₄
• CAS No.: 1469287-58-8
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Mol file: 1469287-58-8.mol

Synonyms:

Chemical Property of C₁₂H₂₁NO₄

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3R,?4R)?-?rel-?1-?[(tert-?Butoxy)?carbonyl]?-?4-?methylpiperidine-?3-?carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3R,?4R)?-?rel-?1-?[(tert-?Butoxy)?carbonyl]?-?4-?methylpiperidine-?3-?carboxylic Acid is a reagent used in the preparation of diacylglycerol acyltransferase 2 inhibitors.

Technology Process of C₁₂H₂₁NO₄

There total 18 articles about C₁₂H₂₁NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C13H23NO4 → C12H21NO4 (1469287-58-8)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01272

Reference yield: 61.0%

1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate (1201192-62-2) → trans 1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid (1271810-25-3,1469287-58-8)

Guidance literature:

1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 30 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate (1201192-62-2) → 1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid (1009376-52-6,1271810-25-3,1469287-58-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 2h; Time;

upstream raw materials:

4-methylpiperidine-3-carboxylic acid

di-tert-butyl dicarbonate

4-methylnicotinic acid

methyl 4-methylpiperidine-3-carboxylate