[1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, 2,6-bis(1,1-dimethylethyl)-4-methylphenyl ester

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, 2,6-bis(1,1-dimethylethyl)-4-methylphenyl ester
• CAS No.: 137600-78-3
• Molecular Formula: C₂₉H₃₄O₂
• Molecular Weight: 414.588
• Mol file: 137600-78-3.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, 2,6-bis(1,1-dimethylethyl)-4-methylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, 2,6-bis(1,1-dimethylethyl)-4-methylphenyl ester

There total 3 articles about [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-, 2,6-bis(1,1-dimethylethyl)-4-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ortho-tolylmagnesium bromide (932-31-0) + 2,6-di-tert-butyl-4-methylphenyl 2-methoxybenzoate (137600-70-5) → 2'-Methyl-biphenyl-2-carboxylic acid 2,6-di-tert-butyl-4-methyl-phenyl ester (137600-78-3)

Guidance literature:

In diethyl ether; benzene; 1.) RT, 20 h, 2.) reflux, 1 h;

DOI:10.1039/c39910001375 DOI:10.1246/bcsj.66.3034

Reference yield:

2,6-di-tert-butyl-4-methyl-phenol (128-37-0) → 2'-Methyl-biphenyl-2-carboxylic acid 2,6-di-tert-butyl-4-methyl-phenyl ester (137600-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / triluoroacetic anhydride / 4 h / Ambient temperature

2: 96 percent / diethyl ether; benzene / 1.) RT, 20 h, 2.) reflux, 1 h

With trifluoroacetic anhydride; In diethyl ether; benzene;

DOI:10.1246/bcsj.66.3034

Reference yield:

2-Methoxybenzoic acid (579-75-9) → 2'-Methyl-biphenyl-2-carboxylic acid 2,6-di-tert-butyl-4-methyl-phenyl ester (137600-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / triluoroacetic anhydride / 4 h / Ambient temperature

2: 96 percent / diethyl ether; benzene / 1.) RT, 20 h, 2.) reflux, 1 h

With trifluoroacetic anhydride; In diethyl ether; benzene;

DOI:10.1246/bcsj.66.3034

upstream raw materials:

ortho-tolylmagnesium bromide

2,6-di-tert-butyl-4-methylphenyl 2-methoxybenzoate

2,6-di-tert-butyl-4-methyl-phenol

2-Methoxybenzoic acid

Downstream raw materials:

2'-methyl[1,1'-biphenyl]-carboxylic acid