Welcome to LookChem.com Sign In|Join Free
  • or

128-37-0

Post Buying Request

128-37-0 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Antioxidant BHT 264 cas 128-37-0
Cas No: 128-37-0
No Data 1 Kilogram 30 Metric Ton/Month Shanghai Bokchang Chemical Science and Technology Co.,Ltd Contact Supplier
Antioxidant 2,6-Di-tert-butyl-4-methylphenol cas 128-37-0
Cas No: 128-37-0
No Data 100 Kilogram 100 Metric Ton/Month Hangzhou Sartort Biopharma Co., Ltd Contact Supplier
CHemwill -- T501 -- 2,6-Di-tert-butyl-4-methylphenol(BHT)
Cas No: 128-37-0
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
Low price with good quality Butylated hydroxytoluene
Cas No: 128-37-0
No Data 100 Kilogram 300 Metric Ton/Day Lonwin Chemical Group Limited Contact Supplier
BHT (food and technical grade) from China // 128-37-0
Cas No: 128-37-0
USD $ 1.0-4.0 / Metric Ton 1 Metric Ton 2000 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
BHT/DBPC/2,6-Di-tert-butyl-4-methylphenol CAS 128-37-0
Cas No: 128-37-0
USD $ 4.5-15.0 / Kilogram 500 Kilogram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Hot selling Butylated Hydroxytoluene CAS 128-37-0 with fast delivery
Cas No: 128-37-0
No Data 25 Kilogram 20 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
BHT CAS No: 128-37-0
Cas No: 128-37-0
No Data 1 Metric Ton 500 Metric Ton/Month HUBEI RISON CHEMICAL CO.,LTD. Contact Supplier
Antioxidant BHT 264
Cas No: 128-37-0
No Data 1 Gram 1-100 Metric Ton/Month CHANGCHUN WEIERSI IMPORT AND EXPORT TRADE CO.,LTD Contact Supplier
Food Grade Antioxidant Butylated Hydroxytoluene BHT
Cas No: 128-37-0
No Data No Data No Data Xiamen Xixiang Supply Chain Co,Ltd Contact Supplier

128-37-0 Usage

storage

Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.

Chemical Properties

BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. BHT has a very faint, musty, occasional cresylictype odor. BHA and BHT are extensively used in foods as antioxidants. Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable. Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts. Antioxidants like BHT act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods (Burdock, 1997).

Safety

Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant. The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight. Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal. LD50 (guinea pig, oral): 10.7 g/kg LD50 (mouse, IP): 0.14 g/kg LD50 (mouse, IV): 0.18 g/kg LD50 (mouse, oral): 0.65 g/kg LD50 (rat, oral): 0.89 g/kg

Carcinogenicity

The IARC has determined that there is limited evidence for the carcinogenicity of BHT in experimental animals. BHT has given primarily negative results in a large number of in vivo and in vitro genotoxic assays. No significant reproductive effects were observed in three-generation toxicity studies in mice administered up to 0.4% in the diet.6 The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2,6-ditert- butyl-p-cresol is 2mg/m3.

Uses

Butylated hydroxytoluene has wide application, such as flavors, fragrances, biochemical reagents-other chemical reagents, chemical raw materials, organic chemical raw materials, biochemical, inorganic salts, antioxidants, food additives, feed additives, feed storage additives, aromatic hydrocarbons, bulk drugs and so on. As a phenolic antioxidant, butylated hydroxytoluene can inhibit lipid peroxidation and exhibit electrophilic quinone methyl ether toxicity mediated by oxidative metabolism. The BHT metabolites, 6-tert-butyl-2- [2 ′-(2′-hydroxymethyl) -propyl] -4-methylphenol, may cause lung damage in mice and promote tumor growth.

Incompatibilities

Contact with oxidizers may cause fire and explosion hazard.

Mammalian physiology

BHT is a phenolic antioxidant. BHT can inhibit lipid peroxidation and cause lung injury in mice and promote tumor growth, which may be due to the metabolites of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-Methylphenol. BHT metabolites have also been reported to cause DNA strand breaks in cultured cells and DNA breaks between nucleosomes (a typical feature of apoptosis). A single intraperitoneal injection of BHT (60mg/kg body weight) into rats caused a significant increase in nuclear DNA methyltransferase activity in the liver, kidney, heart, spleen, brain, and lung.

Contact allergens

This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.

Uses

Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiskinning agent in paints and inks.

Chemical Properties

white crystalline solid

Health Hazard

2,6-Di-tert-butyl-p-cresol or BHT is of relatively low acute toxicity in animals, and there is no evidence of either acute or chronic effects among exposed workers.

Uses

Because they prevent rancidity, antioxidants are of great interest to the food industry. For example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products. Butylated hydroxytoluene is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.

Chemical Properties

Butylated hydroxytoluene(BHT) is white or light yellow crystal. BHT has a melting point of 71°C, a boiling point of 265°C, a relative density of 1.048 (20/4°C), and a refractive index of 1.4859 (75°C). Solubility of BHT at normal temperature: methanol 25, ethanol 25-26, isopropanol 30, mineral oil 30, acetone 40, petroleum ether 50, benzene 40, lard (40-50°C ) 40-50, corn oil and soybean oil 40-50. BHT is insoluble in water, 10NaOH solution, glycerol, and propylene glycol. BHT is odorless, odorless with good thermal stability.

General Description

White crystalline solid.

Chemical Properties

Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

Purification Methods

Dissolve BHT in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]

Description

The antioxidant butylated hydroxytoluene is contained in food, adhesive glues, industrial oils and greases, including cutting fluids. Sensitization seems very rare.

Application from Literature

The applications of butylated hydroxytoluene (BHT) have been reported as following [1-9]: ? Butylated hydroxytoluene metabolites causing DNA strand breaks in cultured cells and DNA breaks between nucleosomes (a typical feature of apoptosis), which result in relieving inflammation. ? Inhibiting secretion, aggregation, and protein phosphorylation caused by protein kinase C activators at the process of the pre-incubation of aspirin-treated platelets. ? Inhibiting liver cancer formation induced by aflatoxin B1. ? As Michael receptor, butylated hydroxytoluene can react with uninucleophiles and proteins. ? Reaction of 2, 6-di-tert-butyl-4-methylphenol with fluorine (II) - benzophenone dianion complex. ? Food additive 2, 6-di-tert-butyl-4-methylphenol can promote acute lung toxicity and tumor growth in mice. ? Butylated hydroxytoluene can be used to prepare organoaluminum compound methylaluminum bis (2, 6-di-tert-butyl-4-alkylphenol oxide).

Uses

BHT is also known as butylated hydroxy toluene. It is an anti-oxidant that also has preservative and masking capabilities.

Incompatibilities

Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.

Occurrence

Not reported found naturally.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Reactivity Profile

Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.

Air & Water Reactions

Insoluble in water.

Pharmaceutical Applications

Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins. Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability. Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

Fire Hazard

2,6-Di-tert-butyl-4-methylphenol is combustible.

Preparation

BHT is produced commercially by the alkylation of para-cresol with isobutylene. BHT is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

Production Methods

Prepared by the reaction of p-cresol with isobutene.

Uses

Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.

Uses

Antioxidant 264 as general antioxidants is used widely in polymer materials, petroleum products and food processing industries. Antioxidant 264 is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm. This product does not change color, not pollution. Antioxidants 264 high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Chemical Properties

BHT is a white to pale yellow crystalline solid or powder.

Potential Exposure

DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.

Safety Profile

Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand.

Definition

ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
InChI:InChI=1/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

128-37-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D0228)  2,6-Di-tert-butyl-p-cresol  >99.0%(GC) 128-37-0 25g 150.00CNY Detail
TCI America (D0228)  2,6-Di-tert-butyl-p-cresol  >99.0%(GC) 128-37-0 500g 285.00CNY Detail
Alfa Aesar (A16863)  2,6-Di-tert-butyl-4-methylphenol, 99%    128-37-0 250g 251.0CNY Detail
Alfa Aesar (A16863)  2,6-Di-tert-butyl-4-methylphenol, 99%    128-37-0 1000g 671.0CNY Detail
Sigma-Aldrich (B1215000)  Butylhydroxytoluene  European Pharmacopoeia (EP) Reference Standard 128-37-0 B1215000 1,880.19CNY Detail
Supelco (47168)  3,5-Di-tert-4-butylhydroxytoluene(BHT)  analytical standard 128-37-0 000000000000047168 224.64CNY Detail
Sigma-Aldrich (PHR1117)  ButylatedHydroxytoluene  pharmaceutical secondary standard; traceable to USP and PhEur 128-37-0 PHR1117-1G 732.19CNY Detail
USP (1082708)  Butylatedhydroxytoluene  United States Pharmacopeia (USP) Reference Standard 128-37-0 1082708-500MG 4,662.45CNY Detail

128-37-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-di-tert-butyl-4-methylphenol

1.2 Other means of identification

Product number -
Other names 2,6-Di-tert-butyl-4-methylphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128-37-0 SDS

128-37-0Synthetic route

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

2,4-Xylenol
105-67-9

2,4-Xylenol

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

2,6-di-tert-butyl-4-(3,5-dimethyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one
131544-07-5

2,6-di-tert-butyl-4-(3,5-dimethyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one

D

3,5-di-tert-butyl-4-hydroxybenzyl 2,4-dimethylphenyl ether
131544-12-2

3,5-di-tert-butyl-4-hydroxybenzyl 2,4-dimethylphenyl ether

Conditions
ConditionsYield
In triethylamineA 3.9%
B 99%
C 54%
D 17%
methanol
67-56-1

methanol

2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With sodium hydroxide; zinc(II) oxide at 200℃; for 8h; Methylation;96%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium hydroxide at 65℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;82%
p-cresol
106-44-5

p-cresol

isobutene
115-11-7

isobutene

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
Stage #1: p-cresol With zinc Autoclave; Heating; Large scale;
Stage #2: isobutene at 70 - 105℃; Large scale;
95.1%
Stage #1: p-cresol With toluene-4-sulfonic acid In water at 56℃; for 9h; Autoclave; Inert atmosphere; Large scale;
Stage #2: isobutene With thiourea In water for 9h; Temperature; Reagent/catalyst; Inert atmosphere; Autoclave; Large scale;
80.9%
With tetraphosphoric acid at 40℃;
With phosphotungstic acid at 90 - 110℃; for 8h; Reagent/catalyst;
C15H25BO2

C15H25BO2

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 0.0833333h; Microwave irradiation; Green chemistry;94%
p-cresol
106-44-5

p-cresol

tert-butyl alcohol
75-65-0

tert-butyl alcohol

A

2-tert-Butyl-4-methylphenol
2409-55-4

2-tert-Butyl-4-methylphenol

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
at 70℃; for 8h; Kinetics; Concentration; Reagent/catalyst; Temperature; Time; Friedel-Crafts alkylation; Ionic liquid; Autoclave; regioselective reaction;A 90%
B 9.5%
With carbon tetrabromide at 175℃; for 6h; Sealed tube;A 68%
B 29%
With carbon tetrabromide at 175℃; for 6h; Sealed tube;A 62%
B 38%
1-butyl-3-methylimidazolium heptachlorodiindate (III) at 110℃; for 4h; Product distribution / selectivity; In ionic liquid;
With multi-walled carbon nanotubes supported on SO3H In neat (no solvent) for 10h; Reagent/catalyst; Reflux;A 85.6 %Chromat.
B 6.7 %Chromat.
4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

phenol
108-95-2

phenol

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-methylcyclohexa-2,5-dienone
13693-18-0

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-methylcyclohexa-2,5-dienone

D

3,5-di-tert-butyl-4-hydroxybenzyl phenyl ether
131544-03-1

3,5-di-tert-butyl-4-hydroxybenzyl phenyl ether

Conditions
ConditionsYield
In triethylamine Further byproducts given;A 14%
B 87%
C 4.6%
D 43%
methyl 3,5-di-tert-butyl-4-hydroxybenzoate
2511-22-0

methyl 3,5-di-tert-butyl-4-hydroxybenzoate

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); 1,1,3,3-Tetramethyldisiloxane; potassium tert-butylate; 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate In toluene at 90℃; for 6h; Reagent/catalyst; Glovebox; Inert atmosphere; Sealed tube;81%
p-cresol
106-44-5

p-cresol

tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

6,6-((4-nitrophenyl)methylene)bis(2-(tert-butyl)4-methylphenol)

6,6-((4-nitrophenyl)methylene)bis(2-(tert-butyl)4-methylphenol)

Conditions
ConditionsYield
With sulfonated multi-walled carbon nanotubes In neat (no solvent) at 100℃; for 4h; Temperature; Concentration; regiospecific reaction;A 8 %Chromat.
B 80%
With sulfonated multi-walled carbon nanotubes In neat (no solvent) for 4h; Reflux; regiospecific reaction;A 33 %Chromat.
B 25%
Carbonic acid tert-butyl ester 2,6-di-tert-butyl-4-methyl-phenyl ester

Carbonic acid tert-butyl ester 2,6-di-tert-butyl-4-methyl-phenyl ester

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 21h; Product distribution; deprotection;79%
3,5-di-tert-butyl-4-hydroxybenzyl alcohol
88-26-6

3,5-di-tert-butyl-4-hydroxybenzyl alcohol

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; chlorobenzene at 120℃; for 4h;77%
With lithium aluminium tetrahydride In tetrahydrofuran; chlorobenzene at 120℃; for 4h; Product distribution; Mechanism; var.reag. NaBH4, CaH2, KH; var. time and solv.;77%
p-cresol
106-44-5

p-cresol

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

tert-butyl alcohol
75-65-0

tert-butyl alcohol

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

6,6-((4-nitrophenyl)methylene)bis(2-(tert-butyl)4-methylphenol)

6,6-((4-nitrophenyl)methylene)bis(2-(tert-butyl)4-methylphenol)

Conditions
ConditionsYield
With sulfonated multi-walled carbon nanotubes In neat (no solvent) at 100℃; for 5h; Concentration; regiospecific reaction;A 18 %Chromat.
B 75%
2,6-di-tert-butyl-4-methylbromobenzene
1206795-79-0

2,6-di-tert-butyl-4-methylbromobenzene

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With iron(III) chloride; potassium phosphate; tetrabutylammomium bromide; N,N`-dimethylethylenediamine In water at 180℃; under 5250.53 Torr; for 20h;47%
methanol
67-56-1

methanol

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With potassium hydroxide; iodine for 2h;A 44%
B 41%
4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
In methanol for 2h;A 44%
B 41%
p-cresol
106-44-5

p-cresol

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

3,5-di-tert-butyl-4-hydroxybenzyl 4-methylphenyl ether
131544-02-0

3,5-di-tert-butyl-4-hydroxybenzyl 4-methylphenyl ether

D

2,6-di-tert-butyl-4-(5-methyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one
131544-08-6

2,6-di-tert-butyl-4-(5-methyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one

Conditions
ConditionsYield
In triethylamine Further byproducts given. Yields of byproduct given;A 11%
B n/a
C 43%
D 8.7%
4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

3,3',5,5'-tetra-tert-butyl-4,4'-stilbenequinone
809-73-4

3,3',5,5'-tetra-tert-butyl-4,4'-stilbenequinone

Conditions
ConditionsYield
In diethyl ether for 0.666667h;A 42%
B 27%
C 19%
2-(allyloxy)-1,3-di-tert-butyl-5-methylbenzene
1516-98-9

2-(allyloxy)-1,3-di-tert-butyl-5-methylbenzene

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

2-allyl-6-(tert-butyl)-4-methylphenol
2253-69-2

2-allyl-6-(tert-butyl)-4-methylphenol

Conditions
ConditionsYield
With phosphomolybdic acid In 1-methyl-pyrrolidin-2-one at 300℃; for 0.0333333h; Claisen Rearrangement; Microwave irradiation; Inert atmosphere;A 15%
B 39%
p-cresol
106-44-5

p-cresol

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

3,5-di-tert-butyl-4-hydroxybenzyl 4-methylphenyl ether
131544-02-0

3,5-di-tert-butyl-4-hydroxybenzyl 4-methylphenyl ether

D

2,6-di-tert-butyl-4-(5-methyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one
131544-08-6

2,6-di-tert-butyl-4-(5-methyl-2-hydroxyphenyl)-4-methylcyclohexa-2,5-dien-1-one

Conditions
ConditionsYield
triethylamine In methanolA 34%
B n/a
C 11%
D 33%
methanol
67-56-1

methanol

2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone
2455-14-3

3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone

C

4,4'-Methylenebis(2,6-di-tert-butylphenol)
118-82-1

4,4'-Methylenebis(2,6-di-tert-butylphenol)

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine; potassium hydroxide at 65℃; Catalytic behavior; Inert atmosphere;A 6%
B n/a
C n/a
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With methanol; sodium hydroxide; formaldehyd at 225℃;
Multi-step reaction with 2 steps
1: water; ethanol / 3 h / 80 °C
2: platinum; hydrogen / 4 h / 160 °C
View Scheme
4,4'-Methylenebis(2,6-di-tert-butylphenol)
118-82-1

4,4'-Methylenebis(2,6-di-tert-butylphenol)

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With sodium methylate at 200℃;
p-cresol
106-44-5

p-cresol

isobutene
115-11-7

isobutene

A

2-tert-Butyl-4-methylphenol
2409-55-4

2-tert-Butyl-4-methylphenol

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With sulfuric acid; glycerol at 20 - 100℃;
With sulfuric acid; glycerol at 70℃;
With acidic ion exchanger
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

methyl iodide
74-88-4

methyl iodide

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

2,6-di-tert-butyl-anisole
1516-95-6

2,6-di-tert-butyl-anisole

C

2,6-Di-tert.-butyl-6-methyl-cyclohexadien-(2,4)-on-(1)
94065-08-4

2,6-Di-tert.-butyl-6-methyl-cyclohexadien-(2,4)-on-(1)

Conditions
ConditionsYield
(i) KOtBu, tBuOH, (ii) /BRN= 969135/; Multistep reaction;
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

4,4'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl
128-38-1

4,4'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl

D

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one
14387-13-4

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one

Conditions
ConditionsYield
In hexane at 30℃; for 1h; Further byproducts given;A 0.01 mol
B 1.89 mol
C 0.85 mol
D 0.02 mol
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one
14387-13-4

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one

Conditions
ConditionsYield
In triethylamine at 30℃; for 1h;A 1.02 mol
B 0.87 mol
2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

2,6-di-tert-butyl-4-methylphenoxy radical
6858-01-1, 24473-56-1

2,6-di-tert-butyl-4-methylphenoxy radical

A

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane
1516-94-5

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)ethane

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C

3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone
2455-14-3

3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone

D

4,4'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl
128-38-1

4,4'-dihydroxy-3,3',5,5'-tetra-tert-butylbiphenyl

E

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one
14387-13-4

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-methyl-2,5-cyclohexadiene-1-one

Conditions
ConditionsYield
In hexane at 30℃; for 1h; Product distribution; Mechanism; other solvents or solvent mixtures; reaction with other phenols;
Ethaneperoxoic acid 3,5-di-tert-butyl-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester
62926-71-0

Ethaneperoxoic acid 3,5-di-tert-butyl-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dienone
10396-80-2

2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dienone

C

(3,5-Di-tert-butyl-1-methyl-4-oxo-cyclohexa-2,5-dienyloxy)-acetic acid
62926-78-7

(3,5-Di-tert-butyl-1-methyl-4-oxo-cyclohexa-2,5-dienyloxy)-acetic acid

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide; Petroleum ether at -60℃; for 2h;A 4 % Spectr.
B 3 % Spectr.
C 81 % Spectr.
4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one
2179-51-3

4-(2,6-di-tert-butyl-4-methylphenoxy)-2,6-di-tert-butyl-4-methyl-2,5-cyclohexadien-1-one

A

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

B

2,6-di-tert-butyl-4-methylene-2,5-cyclohexadien-1-one
2607-52-5

2,6-di-tert-butyl-4-methylene-2,5-cyclohexadien-1-one

Conditions
ConditionsYield
In chloroform
2,6-Di-t-butyl-4-methoxyphenol
489-01-0

2,6-Di-t-butyl-4-methoxyphenol

2,6-di-tert-butyl-4-methylphenoxy radical
6858-01-1, 24473-56-1

2,6-di-tert-butyl-4-methylphenoxy radical

A

2,6-di-tert-butyl-4-methoxyphenoxyl radical
20137-67-1, 3425-36-3

2,6-di-tert-butyl-4-methoxyphenoxyl radical

B

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
In toluene; benzene at -22.1 - 30.9℃; Equilibrium constant; Thermodynamic data; ΔH, ΔS;
In benzene Equilibrium constant; Thermodynamic data; Ambient temperature; ΔG; also in tert-butanol;
In benzene Thermodynamic data; Η, Σ;
2,6-di-tert-butyl-4-methylphenoxy radical
6858-01-1, 24473-56-1

2,6-di-tert-butyl-4-methylphenoxy radical

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone In benzene at 24.9℃; Equilibrium constant;
With Methyl oleate at 20℃; Kinetics; Further Variations:; Reagents;
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

acetic anhydride
108-24-7

acetic anhydride

2,6-ditertbutyl-4-methylphenyl acetate
29311-34-0

2,6-ditertbutyl-4-methylphenyl acetate

Conditions
ConditionsYield
With perchloric acid at 20℃; for 0.25h;100%
cerium triflate In acetonitrile at 50℃; for 24h;98%
With silica gel-supported phosphotungstic acid In chloroform at 62℃; for 0.0833333h;98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

Carbonic acid tert-butyl ester 2,6-di-tert-butyl-4-methyl-phenyl ester

Carbonic acid tert-butyl ester 2,6-di-tert-butyl-4-methyl-phenyl ester

Conditions
ConditionsYield
With dmap In hexane for 28h;100%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

methyl 2-(2,6-di-tert-butyl-4-methylphenoxy)acetate
1572184-69-0

methyl 2-(2,6-di-tert-butyl-4-methylphenoxy)acetate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 16h; Reflux;100%
tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

2,6-di-tert-butyl-4-(tert-butylperoxy)-4-methylcyclohexa-2,5-dien-1-one
13154-57-9

2,6-di-tert-butyl-4-(tert-butylperoxy)-4-methylcyclohexa-2,5-dien-1-one

Conditions
ConditionsYield
With dirhodium(II) tetrakis(caprolactam) In water; 1,2-dichloro-ethane at 40℃; for 0.75h; chemoselective reaction;99%
With tetra-(n-butyl)ammonium iodide In nonane; 1,2-dichloro-ethane at 20℃; for 24h;99%
With cobalt naphthenate
(electrochemical oxidation);
With sodium chloride; sodium hydroxide; benzyl alcohol In water at 70℃; for 12h; Sealed tube; Green chemistry;
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dienone
10396-80-2

2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dienone

Conditions
ConditionsYield
With cesium hydroxide; oxygen; triethyl phosphite In dimethyl sulfoxide at 25℃; under 760.051 Torr; for 12h;99%
With oxygen; Cu4Cl4O2 (CH3CN)3 In acetonitrile under 760 Torr; Ambient temperature;95%
With perchloric acid; water; lead dioxide In acetone for 0.133333h;89%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

propionyl chloride
79-03-8

propionyl chloride

2,6-di-tert-butyl-4-methylphenyl propionate
72959-50-3

2,6-di-tert-butyl-4-methylphenyl propionate

Conditions
ConditionsYield
Stage #1: 2,6-di-tert-butyl-4-methyl-phenol With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: propionyl chloride In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;
99%
With n-butyllithium In tetrahydrofuran; hexane at 0℃;96%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In 1,4-dioxane Ambient temperature;
With n-butyllithium 1)THF, hexane 0 deg C; Yield given. Multistep reaction;
1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane
423-39-2

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

2,6-ditert-butyl-4-methyl-4-(1,1,2,2,3,3,4,4,4-nonafluorobuta-1-yl)cyclohexa-2,5-dien-1-one

2,6-ditert-butyl-4-methyl-4-(1,1,2,2,3,3,4,4,4-nonafluorobuta-1-yl)cyclohexa-2,5-dien-1-one

Conditions
ConditionsYield
With water; caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Irradiation;99%
With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; Irradiation;95%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

1-bromocyclopentane-carboxylic acid ethyl ester
30038-94-9

1-bromocyclopentane-carboxylic acid ethyl ester

benzyl 1-(3,5-di-tert-butyl-1-methyl-4-oxocyclohexa-2,5-dien-1-yl)cyclopentane-1-carboxylate

benzyl 1-(3,5-di-tert-butyl-1-methyl-4-oxocyclohexa-2,5-dien-1-yl)cyclopentane-1-carboxylate

Conditions
ConditionsYield
With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,4'-di-tert-butyl-2,2'-bipyridine In toluene at 20℃; for 1h; Inert atmosphere;99%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

2,6-di-tert-butyl-4-methylcyclohexanol
163119-16-2

2,6-di-tert-butyl-4-methylcyclohexanol

Conditions
ConditionsYield
With hydrogen In water at 60℃; under 7500.75 Torr; for 12h; Autoclave;98.1%
With palladium on activated charcoal; potassium tert-butylate; hydrogen In ethyl acetate at 90℃; under 3000.3 Torr; for 0.25h; Temperature; Pressure; Autoclave;95.3%
With nickel(II) oxide; hydrogen; palladium In hexane at 130℃; under 37503.8 Torr; for 12h;84%
With 5% rhodium on activated aluminium oxide; 10.3% Ni/Al2O3 In isopropyl alcohol at 160℃; under 75007.5 Torr; for 12h; Temperature; Reagent/catalyst; Pressure; Autoclave;
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

3,3',5,5'-tetra-tert-butyl-4,4'-stilbenequinone
809-73-4

3,3',5,5'-tetra-tert-butyl-4,4'-stilbenequinone

Conditions
ConditionsYield
Stage #1: 2,6-di-tert-butyl-4-methyl-phenol With potassium iodide In isopropyl alcohol at 70℃; for 0.5h;
Stage #2: With dihydrogen peroxide In isopropyl alcohol at 70 - 75℃; for 9h;
98%
Stage #1: 2,6-di-tert-butyl-4-methyl-phenol With potassium iodide In isopropyl alcohol at 70℃; for 0.5h;
Stage #2: With dihydrogen peroxide In water; isopropyl alcohol at 70 - 75℃; for 9h;
98%
Stage #1: 2,6-di-tert-butyl-4-methyl-phenol With potassium iodide In isopropyl alcohol at 70℃; for 0.5h;
Stage #2: With dihydrogen peroxide In water; isopropyl alcohol at 70 - 75℃; for 9h;
98%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

4-bromo-4-bromomethyl-2,6-di-t-butyl-2,5-cyclohexadienone
25534-61-6

4-bromo-4-bromomethyl-2,6-di-t-butyl-2,5-cyclohexadienone

Conditions
ConditionsYield
With benzyltrimethylammonium tribromide In dichloromethane; water for 3h; Ambient temperature;98%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

triisobutylaluminum
100-99-2

triisobutylaluminum

isobutylbis(3,5-di-tert-butyl-4-hydroxytoluene)aluminum
56252-57-4

isobutylbis(3,5-di-tert-butyl-4-hydroxytoluene)aluminum

Conditions
ConditionsYield
In pentane byproducts: isobutane; under Ar; soln. of 2,6-di-tert-butyl-4-methylphenol added to soln. of triisobutylaluminum (30 min); refluxed with stirring (70 min); cooled to room temp.; pentane removed (vac.);98%
In n-heptane Addn. of H-BHT soln. to Al(i-Bu)3 soln. under reflux (70 min), stirring and refluxing (70 min), cooling to room temp.; Evapn., recrystn. (heptane), cooling (to -35°C), filtn., elem. anal.;78.1%
In pentane
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

trimethylaluminum
75-24-1

trimethylaluminum

bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum
56252-55-2

bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum

Conditions
ConditionsYield
In hexane (Ar); std. Schlenk technique; soln. of Me3Al in hexane was slowly added over 5 min to stirred soln. of phenol in hexane; soln. was stirred at 25°C for 1 h; evapd. in vac. overnight;98%
In hexane; benzene To a benzene soln. of phenol is added a hexane soln. of AlMe3 at room temp. under N2. The soln. is refluxed for 3 h and cooled.; evapn., recrystn. from boiling pentane; IR, NMR;91%
In toluene N2-atmosphere; addn. of 2 equiv. of phenol derivative to AlMe3 at -78°C, stirring (room temp., 1 h); solvent removal, dissoln. in hexane/hot PhMe, crystn. (room temp., 12 h); elem. anal.;89%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

aluminum isopropoxide
555-31-7

aluminum isopropoxide

{Al(CH3CHOCH3)2((CH3CH3CCH3)2CH3C6H2O)}

{Al(CH3CHOCH3)2((CH3CH3CCH3)2CH3C6H2O)}

Conditions
ConditionsYield
In benzene Stoichiometric quantity of a soln. of Al(OCH3CHCH3)3 in C6H6 is refluxed with phenol derivate for 6 h, benzene-isopropanol azeotrope is colected, exess solvent is removed under reduced pressure.; Elem. anal.;98%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C15H24O(18)O

C15H24O(18)O

Conditions
ConditionsYield
With cesium hydroxide; oxygen-18; triethyl phosphite In dimethyl sulfoxide at 25℃; under 760.051 Torr; for 12h; Mechanism;98%
tetrahydrofuran
109-99-9

tetrahydrofuran

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

dibutylmagnesium
1191-47-5

dibutylmagnesium

2,6-di-tertbutyl-4-methylphenoxide

2,6-di-tertbutyl-4-methylphenoxide

Conditions
ConditionsYield
Stage #1: 2,6-di-tert-butyl-4-methyl-phenol; dibutylmagnesium In n-heptane; toluene at 20 - 60℃; for 2h;
Stage #2: tetrahydrofuran for 2h;
98%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-(2,6-di-tert-butyl-4-methylphenoxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(2,6-di-tert-butyl-4-methylphenoxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With triethylamine In [D3]acetonitrile at 120℃; Inert atmosphere;98%
With styrene; silver hexafluoroantimonate at 60℃; for 24h; Inert atmosphere; Glovebox;
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

C40H99N13P4

C40H99N13P4

C15H24O*C40H99N13P4

C15H24O*C40H99N13P4

Conditions
ConditionsYield
In diethyl ether at 20℃;98%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

3,5-di-tert-butyl-4-hydroxybenzyl alcohol
88-26-6

3,5-di-tert-butyl-4-hydroxybenzyl alcohol

Conditions
ConditionsYield
With benzyltrimethylammonium tribromide In dichloromethane; water for 0.5h; Ambient temperature;97%
Multi-step reaction with 2 steps
1: bromine; aqueous acetic acid
2: LiAlH4; diethyl ether
View Scheme
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

lithium 2,6-di-tert-butyl-4-methylphenoxide
42031-71-0

lithium 2,6-di-tert-butyl-4-methylphenoxide

Conditions
ConditionsYield
With n-butyllithium In diethyl ether; hexane at 0℃; for 0.5h;97%
With n-butyllithium In thiophene; hexane at 0 - 20℃; Title compound not separated from byproducts;
[Zn(μ-1,1,3,3-tetramethylguanidinato)(Et)]3
1000401-33-1

[Zn(μ-1,1,3,3-tetramethylguanidinato)(Et)]3

2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

[Zn(1,1,3,3-tetramethylguanidine)(Et)(OC6H2(CMe3)2-2,6-Me-4)]
1000401-36-4

[Zn(1,1,3,3-tetramethylguanidine)(Et)(OC6H2(CMe3)2-2,6-Me-4)]

Conditions
ConditionsYield
In hexane (Ar); addn. dropwise of soln. of HOC6H2(Me)(CMe3)2 (3 equiv.) to stirredsoln. of (Zn(μ-1,1,3,3-tetramethylguanidine)Et)3 (1 equiv.) in hexan e; stirring for 15 min; evapn., recrystn. from concd. hexanes soln. at -37°C; elem. anal..;97%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

n-valeryl chloride
638-29-9

n-valeryl chloride

2,6-di-tert-butyl-4-methylphenyl pentanoate
1420117-15-2

2,6-di-tert-butyl-4-methylphenyl pentanoate

Conditions
ConditionsYield
With potassium iodide In acetonitrile at 82℃; for 24h; Friedel-Crafts Acylation; Inert atmosphere; Sealed tube;97%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

A

p-cresol
106-44-5

p-cresol

B

4-tert-butyltoluene
98-51-1

4-tert-butyltoluene

Conditions
ConditionsYield
With Nafion-H; toluene for 2h; Heating;A 96%
B 94 % Chromat.
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

toluene
108-88-3

toluene

A

p-cresol
106-44-5

p-cresol

B

4-tert-butyltoluene
98-51-1

4-tert-butyltoluene

Conditions
ConditionsYield
With Nafion-H for 2h; Heating;A 96%
B 94 % Chromat.
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone
6485-57-0

2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone

Conditions
ConditionsYield
With 2,8-dibromo-5,5-difluoro-1,3,7,9-tetramethyl-10-phenyl-5H-dipyrrolo[1,2-c:2′,1′-f ][1,3,2]diazaborinin-4-ium-5-uide; oxygen In 1,4-dioxane for 6h; Irradiation;95%
With potassium hydroxide; oxygen
With cobalt naphthenate; dihydrogen peroxide; tert-butyl alcohol
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

3,5-di-t-butyl-4-hydroxybenzaldehyde
1620-98-0

3,5-di-t-butyl-4-hydroxybenzaldehyde

Conditions
ConditionsYield
With bromine In tert-butyl alcohol at 25℃; for 1h;95%
With N-Bromosuccinimide; dimethyl sulfoxide93%
With iodine; potassium carbonate In methanol for 0.416667h;85%
2,6-di-tert-butyl-4-methyl-phenol
128-37-0

2,6-di-tert-butyl-4-methyl-phenol

acetyl chloride
75-36-5

acetyl chloride

2,6-ditertbutyl-4-methylphenyl acetate
29311-34-0

2,6-ditertbutyl-4-methylphenyl acetate

Conditions
ConditionsYield
With potassium iodide In acetonitrile at 82℃; for 24h; Friedel-Crafts Acylation; Inert atmosphere; Sealed tube;95%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In 1,4-dioxane Ambient temperature;
With n-butyllithium Yield given. Multistep reaction;

128-37-0Downstream Products

128-37-0Related news

In vitro and in vivo effect of 2,6-Di-tert-butyl-4-methylphenol (cas 128-37-0) as an antibiofilm agent against quorum sensing mediated biofilm formation of Vibrio spp.09/28/2019

This study unveils the in vitro and in vivo antibiofilm potential of 2,6-Di-tert-butyl-4-methylphenol (DTBMP) from Chroococcus turgidus against Vibrio spp. In the preliminary study, cell free culture supernatant (CFCS) of C. turgidus inhibited the violacein production in biomarker strain Chromob...detailed

Radiolysis of 2,6-Di-tert-butyl-4-methylphenol (cas 128-37-0) (ionol) in a lipid membrane in the presence of oxygen09/27/2019

Radiation-induced destruction of the ionol molecules in liposomes built of L-α-lecithin depends on the ionol concentration in the lipids and on the concentration of the lipid in the dispersion.detailed

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields