2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Base Information

Chemical Name:2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine
CAS No.:1320288-64-9
Molecular Formula:C₂₉H₄₇N₅O₃
Molecular Weight:513.724
Hs Code.:

Synonyms:

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Chemical Property of 2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Chemical Property:

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Technology Process of 2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

There total 8 articles about 2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 385785-02-4
2-amino-4-(benzyloxy)-5-methoxybenzonitrile

: 1320288-64-9
2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

5: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 2 h / Reflux

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 6: Mitsunobu reaction;
DOI:10.1021/jm200903z

Reference yield:

: 385784-84-9
4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile

: 1320288-64-9
2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: water; iron; ammonium chloride / isopropyl alcohol / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

6: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 2 h / Reflux

7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; dihydrogen peroxide; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 7: Mitsunobu reaction;
DOI:10.1021/jm200903z

Reference yield:

: C₂₂H₂₄N₂O₃

: 1320288-64-9
2-cyclohexyl-7-(2-(2-(dimethylamino)ethoxy)ethoxy)-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

2: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

4: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 2 h / Reflux

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; isopropyl alcohol; 5: Mitsunobu reaction;
DOI:10.1021/jm200903z