Multi-step reaction with 15 steps
1: lithium diisopropyl amide / tetrahydrofuran
2: lithium diisopropyl amide / tetrahydrofuran
3: sodium tetrahydroborate / methanol
4: dibromotriphenylphosphorane / acetonitrile
5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / water; 1,4-dioxane
6: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene
7: bromine; dibenzoyl peroxide / tetrachloromethane / UV-irradiation
8: boron trifluoride diethyl etherate / tetrahydrofuran
9: lithium triethylborohydride / tetrahydrofuran
10: dibromotriphenylphosphorane / acetonitrile
11: lithium triethylborohydride / tetrahydrofuran
12: bromine / chloroform
13: iodine; acetic acid; periodic acid
14: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C
15: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / water; 1,4 dimethylcyclohexane
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); boron trifluoride diethyl etherate; bromine; iodine; potassium acetate; lithium triethylborohydride; sodium carbonate; acetic acid; periodic acid; lithium diisopropyl amide; dibromotriphenylphosphorane; dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1,4 dimethylcyclohexane;
5: |Miyaura Borylation Reaction;