Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride

Base Information

• Chemical Name: Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride
• CAS No.: 146508-48-7
• Molecular Formula: C₁₄H₁₈ClN*ClH
• Molecular Weight: 272.218
• Mol file: 146508-48-7.mol

Synonyms:

Chemical Property of Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride

There total 5 articles about Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohepta-1,3-diene (876938-53-3) → Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride (113340-16-2,146508-48-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / Me₄NIO₄ / CHCl₃; dimethylformamide

2: 92 percent / Al/Hg / tetrahydrofuran; H₂O

3: 97 percent / LiAlH₄ / diethyl ether

4: SOCl₂/LiCl / CHCl₃

With aluminum amalgam; lithium aluminium tetrahydride; thionyl chloride; tetramethylammonium metaperiodate; lithium chloride; In tetrahydrofuran; diethyl ether; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)81095-9

Reference yield:

Benzohydroxamic acid (495-18-1) → Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride (113340-16-2,146508-48-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / Me₄NIO₄ / CHCl₃; dimethylformamide

2: 92 percent / Al/Hg / tetrahydrofuran; H₂O

3: 97 percent / LiAlH₄ / diethyl ether

4: SOCl₂/LiCl / CHCl₃

With aluminum amalgam; lithium aluminium tetrahydride; thionyl chloride; tetramethylammonium metaperiodate; lithium chloride; In tetrahydrofuran; diethyl ether; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)81095-9

Reference yield:

cis-4-(benzoylamino)-2-cycloheptenol (95687-90-4) → Benzyl-((1R,4R)-4-chloro-cyclohept-2-enyl)-amine; hydrochloride (113340-16-2,146508-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / LiAlH₄ / diethyl ether

2: SOCl₂/LiCl / CHCl₃

With lithium aluminium tetrahydride; thionyl chloride; lithium chloride; In diethyl ether; chloroform;

DOI:10.1016/S0040-4039(01)81095-9

upstream raw materials:

4-(N-benzylamino)cyclohept-2-en-1-ol

Cyclohepta-1,3-diene

Benzohydroxamic acid

cis-4-(benzoylamino)-2-cycloheptenol

Downstream raw materials:

8-Benzyl-8-aza-bicyclo[5.1.0]oct-2-ene

8-benzyl-8-azabicyclo(3.2.1)oct-6-ene