V⁽⁰⁹¹⁾U₀₄₀₆

Base Information

Chemical Name:V⁽⁰⁹¹⁾U₀₄₀₆
CAS No.:1276617-62-9
Molecular Formula:C₁₅H₁₁FN₄O₂S
Molecular Weight:330.342
Hs Code.:

Synonyms:

Suppliers and Price of V⁽⁰⁹¹⁾U₀₄₀₆

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VU0409106
100mg
$ 1080.00

Tocris
VU0409106 ≥98%(HPLC)
10
$ 164.00

Total 3 raw suppliers

Chemical Property of V⁽⁰⁹¹⁾U₀₄₀₆

Chemical Property:

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

VU0409106 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.

Technology Process of V⁽⁰⁹¹⁾U₀₄₀₆

There total 4 articles about V⁽⁰⁹¹⁾U₀₄₀₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276619-83-0
3-fluoro-5-(pyrimidin-5-yloxy)benzonitrile

: 1276617-62-9
V⁽⁰⁹¹⁾U₀₄₀₆

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 100 °C / Sealed tube

2: sulfuric acid / Reflux

3: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.09.001

Reference yield:

: 1276619-84-1
3-fluoro-5-(pyrimidin-5-yloxy)benzoic acid

: 1276617-62-9
V⁽⁰⁹¹⁾U₀₄₀₆

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2013.09.001

Reference yield:

: 64248-63-1
3,5-difluorobenzonitrile

: 1276617-62-9
V⁽⁰⁹¹⁾U₀₄₀₆

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 150 °C

2: sodium hydroxide / water / 100 °C / Sealed tube

3: sulfuric acid / Reflux

4: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.09.001