Technology Process of 1,2-dibenzyl 3-methyl (5Z)-5-benzylidenepyrazolidine-1,2,3-tricarboxylate
There total 8 articles about 1,2-dibenzyl 3-methyl (5Z)-5-benzylidenepyrazolidine-1,2,3-tricarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver tetrafluoroborate; (triphenylphosphine)gold(I) chloride;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
Solvent;
Reagent/catalyst;
diastereoselective reaction;
Catalytic behavior;
Schlenk technique;
Inert atmosphere;
Darkness;
DOI:10.1021/jo302320v
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 16 h / 60 °C / Schlenk technique; Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -45 °C
2.2: 1 h / 20 °C
3.1: rac-Pro-OH / acetonitrile / 16 h / 20 °C
4.1: potassium dihydrogenphosphate; sodium chlorite monohydrate; dihydrogen peroxide / methanol; acetonitrile; water / 1 h / 20 °C
5.1: methanol; toluene; hexane / 0.25 h / 20 °C
6.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 16 h / 20 °C / Schlenk technique; Inert atmosphere; Darkness
With
bis-triphenylphosphine-palladium(II) chloride; potassium dihydrogenphosphate; copper(l) iodide; silver tetrafluoroborate; oxalyl dichloride; (triphenylphosphine)gold(I) chloride; sodium chlorite monohydrate; dihydrogen peroxide; dimethyl sulfoxide; rac-Pro-OH;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo302320v
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 16 h / 60 °C / Schlenk technique; Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -45 °C
2.2: 1 h / 20 °C
3.1: rac-Pro-OH / acetonitrile / 16 h / 20 °C
4.1: potassium dihydrogenphosphate; sodium chlorite monohydrate; dihydrogen peroxide / methanol; acetonitrile; water / 1 h / 20 °C
5.1: methanol; toluene; hexane / 0.25 h / 20 °C
6.1: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / tetrahydrofuran / 16 h / 20 °C / Schlenk technique; Inert atmosphere; Darkness
With
bis-triphenylphosphine-palladium(II) chloride; potassium dihydrogenphosphate; copper(l) iodide; silver tetrafluoroborate; oxalyl dichloride; (triphenylphosphine)gold(I) chloride; sodium chlorite monohydrate; dihydrogen peroxide; dimethyl sulfoxide; rac-Pro-OH;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo302320v