Technology Process of methyl 2-(1,2-dibenzyloxycarbonylhydrazinyl)-5-phenylpent-4-ynoate
There total 6 articles about methyl 2-(1,2-dibenzyloxycarbonylhydrazinyl)-5-phenylpent-4-ynoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 16 h / 60 °C / Schlenk technique; Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -45 °C
2.2: 1 h / 20 °C
3.1: rac-Pro-OH / acetonitrile / 16 h / 20 °C
4.1: potassium dihydrogenphosphate; sodium chlorite monohydrate; dihydrogen peroxide / methanol; acetonitrile; water / 1 h / 20 °C
5.1: methanol; toluene; hexane / 0.25 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium dihydrogenphosphate; copper(l) iodide; oxalyl dichloride; sodium chlorite monohydrate; dihydrogen peroxide; dimethyl sulfoxide; rac-Pro-OH;
In
methanol; hexane; dichloromethane; water; toluene; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo302320v
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -45 °C
1.2: 1 h / 20 °C
2.1: rac-Pro-OH / acetonitrile / 16 h / 20 °C
3.1: potassium dihydrogenphosphate; sodium chlorite monohydrate; dihydrogen peroxide / methanol; acetonitrile; water / 1 h / 20 °C
4.1: methanol; toluene; hexane / 0.25 h / 20 °C
With
potassium dihydrogenphosphate; oxalyl dichloride; sodium chlorite monohydrate; dihydrogen peroxide; dimethyl sulfoxide; rac-Pro-OH;
In
methanol; hexane; dichloromethane; water; toluene; acetonitrile;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation;
DOI:10.1021/jo302320v
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 16 h / 60 °C / Schlenk technique; Inert atmosphere
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -45 °C
2.2: 1 h / 20 °C
3.1: rac-Pro-OH / acetonitrile / 16 h / 20 °C
4.1: potassium dihydrogenphosphate; sodium chlorite monohydrate; dihydrogen peroxide / methanol; acetonitrile; water / 1 h / 20 °C
5.1: methanol; toluene; hexane / 0.25 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium dihydrogenphosphate; copper(l) iodide; oxalyl dichloride; sodium chlorite monohydrate; dihydrogen peroxide; dimethyl sulfoxide; rac-Pro-OH;
In
methanol; hexane; dichloromethane; water; toluene; acetonitrile;
1.1: |Sonogashira Cross-Coupling / 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo302320v