Technology Process of (R)-5,7-dimethoxy-3-(4-methoxybenzyl)chroman-4-one
There total 9 articles about (R)-5,7-dimethoxy-3-(4-methoxybenzyl)chroman-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; methanesulfonamide; potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; potassium hexacyanoferrate(III);
In
water; tert-butyl alcohol;
at 0 ℃;
for 24h;
Overall yield = 66 %; enantioselective reaction;
DOI:10.1080/10426507.2014.980411
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen bromide; sulfuric acid
2.1: potassium carbonate
3.1: potassium hydroxide; water / acetone
4.1: trifluoroacetic anhydride / dichloromethane / Heating
5.1: hydrogen; palladium on activated charcoal / ethyl acetate / 24 h
6.1: lithium diisopropyl amide / -78 °C
6.2: -78 °C
7.1: potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; potassium hexacyanoferrate(III); osmium(VIII) oxide; methanesulfonamide / tert-butyl alcohol; water / 24 h / 0 °C
With
osmium(VIII) oxide; methanesulfonamide; sulfuric acid; palladium on activated charcoal; water; hydrogen bromide; hydrogen; potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; trifluoroacetic anhydride; potassium hydroxide; potassium hexacyanoferrate(III); lithium diisopropyl amide;
In
dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1080/10426507.2014.980411
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide; water / acetone
2.1: trifluoroacetic anhydride / dichloromethane / Heating
3.1: hydrogen; palladium on activated charcoal / ethyl acetate / 24 h
4.1: lithium diisopropyl amide / -78 °C
4.2: -78 °C
5.1: potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; potassium hexacyanoferrate(III); osmium(VIII) oxide; methanesulfonamide / tert-butyl alcohol; water / 24 h / 0 °C
With
osmium(VIII) oxide; methanesulfonamide; palladium on activated charcoal; water; hydrogen; potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; trifluoroacetic anhydride; potassium hydroxide; potassium hexacyanoferrate(III); lithium diisopropyl amide;
In
dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1080/10426507.2014.980411
