benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Base Information

Chemical Name:benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate
CAS No.:1235563-87-7
Molecular Formula:C₅₂H₆₆N₁₁O₁₅P
Molecular Weight:1116.13
Hs Code.:

benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

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Chemical Property of benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

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Technology Process of benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

There total 8 articles about benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl phosphonate: 762-04-9,123-22-8
Diethyl phosphonate

: 1235563-93-5
benzyl 1-oxo-2,3-dihydro-1H-indene-5-carboxylate

: C₂HF₃O₂*C₃₁H₄₃N₁₁O₁₀

: 1235563-87-7
benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: benzyl 1-oxo-2,3-dihydro-1H-indene-5-carboxylate; C₂HF₃O₂*C₃₁H₄₃N₁₁O₁₀; With [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 30 ℃; for 3h; Molecular sieve;

Diethyl phosphonate; In dichloromethane; at 30 ℃; for 96h; Molecular sievec;
DOI:10.1007/s11172-010-0063-x

Reference yield:

: 2188-18-3
Boc-Arg(NO₂)-OH

: 1235563-87-7
benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 14 h / 0 - 5 °C

1.2: 16 h / 4 °C

2.1: dichloromethane / 4 h

3.1: [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 30 °C / Molecular sieve

3.2: 96 h / 30 °C / Molecular sievec

With [tetra(tert-butyl)phthalocyanine]aluminium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; 3.1: Kabachnik-Fields reaction / 3.2: Kabachnik-Fields reaction;
DOI:10.1007/s11172-010-0063-x

Reference yield:

: 94770-45-3
benzyl Nα-Boc-Nω-nitro-L-argininate

: 1235563-87-7
benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2 h

2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

3.1: 2 h

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 14 h / 0 - 5 °C

4.2: 16 h / 4 °C

5.1: dichloromethane / 4 h

6.1: [tetra(tert-butyl)phthalocyanine]aluminium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 30 °C / Molecular sieve

6.2: 96 h / 30 °C / Molecular sievec

With [tetra(tert-butyl)phthalocyanine]aluminium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 6.1: Kabachnik-Fields reaction / 6.2: Kabachnik-Fields reaction;
DOI:10.1007/s11172-010-0063-x