benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Base Information

• Chemical Name: benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate
• CAS No.: 1235563-75-3
• Molecular Formula: C₃₆H₅₁N₁₁O₁₂
• Molecular Weight: 829.867

Synonyms:benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Chemical Property of benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

There total 6 articles about benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Boc-Arg(NO2)-OH (2188-18-3) + benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate (1235563-92-4) → benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate (1235563-75-3)

Guidance literature:

Boc-Arg(NO₂)-OH; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 5 ℃; for 14h;

benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 4 ℃; for 16h;

DOI:10.1007/s11172-010-0063-x

Reference yield:

benzyl chloride (100-44-7) → benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate (1235563-75-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 7 h / 80 °C

2.1: 2 h

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 4 °C

4.1: 2 h

5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 14 h / 0 - 5 °C

5.2: 16 h / 4 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1007/s11172-010-0063-x

Reference yield:

benzyl Nα-Boc-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate (149836-44-2) → benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate (1235563-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2 h

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 14 h / 0 - 5 °C

2.2: 16 h / 4 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1007/s11172-010-0063-x

upstream raw materials:

benzyl Nα-Boc-Nω-nitro-L-argininate

benzyl Nα-Boc-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Boc-Arg(NO₂)-OH

benzyl (γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate trifluoroacetate

Downstream raw materials:

benzyl [Nα-(1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

benzyl [Nα-(5-benzyloxycarbonyl-1-(diethoxyphosphoryl)-2,3-dihydro-1H-inden-1-yl)-Nω-nitro-L-arginyl]-(γ-benzyl)-α-L-glutamyl-Nω-nitro-L-argininate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1235563-75-3 benzyl Nα-Boc-Nω-nitro-L-arginyl-(γ-benzyl α-L-glutamyl)-Nω-nitro-L-argininate

Send

Send

Metric Ton KG G Pound L ML

Send

Send