N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Base Information

Chemical Name:N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide
CAS No.:137302-75-1
Molecular Formula:C₃₆H₅₅F₂N₇O₇S
Molecular Weight:767.938
Hs Code.:

N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

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Technology Process of N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

There total 11 articles about N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137302-68-2
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

: 137302-75-1,137429-62-0
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: With dichloro-acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In dichloromethane; Yield given; 1.) 0 deg C, 2.) RT, 18 h;
DOI:10.1021/jm00079a001

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 137302-75-1,137429-62-0
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 8 steps

1: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

3: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

4: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

5: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

6: HCl / CHCl₃

7: 59 percent / formic acid / ethanol / 3 h / Heating

8: dichloroacetic acid, DCC, DMSO / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 18 h

With hydrogenchloride; dichloro-acetic acid; formic acid; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 137302-75-1,137429-62-0
N-<(4-methyl-1-piperazinyl)sulfonyl>-L-phenylalanyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 10 steps

1: Zn, I₂ / tetrahydrofuran / 0.5 h / Heating

2: 79 percent / NaOH / tetrahydrofuran / 4 h

3: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

4: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

5: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

6: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

7: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

8: HCl / CHCl₃

9: 59 percent / formic acid / ethanol / 3 h / Heating

10: dichloroacetic acid, DCC, DMSO / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 18 h

With hydrogenchloride; dichloro-acetic acid; sodium hydroxide; formic acid; iodine; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001