4-Bromo-2,5-dimethylthiophene-3-carbaldehyde

Base Information

• Chemical Name: 4-Bromo-2,5-dimethylthiophene-3-carbaldehyde
• CAS No.: 887575-78-2
• Molecular Formula: C₇H₇BrOS
• Molecular Weight: 219.102
• European Community (EC) Number: 856-607-3

Synonyms:4-bromo-2,5-dimethylthiophene-3-carbaldehyde;887575-78-2;EN300-696758;Z2182013577

Chemical Property of 4-Bromo-2,5-dimethylthiophene-3-carbaldehyde

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 217.94010
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2,5-dimethylthiophene-3-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=C(S1)C)Br)C=O

Technology Process of 4-Bromo-2,5-dimethylthiophene-3-carbaldehyde

There total 2 articles about 4-Bromo-2,5-dimethylthiophene-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dibromo-2,5-dimethylthiophene (39129-54-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2,5-dimethyl-thiophene-3-carbaldehyde (887575-78-2)

Guidance literature:

2,5-dimethyl-3,4-dibromothiophene; With n-butyllithium; In diethyl ether; at -78 ℃;

N,N-dimethyl-formamide; In diethyl ether; at -78 ℃;

DOI:10.1055/s-2002-35577

Reference yield:

2,5-DIMETHYLTHIOPHENE (638-02-8) → 4-bromo-2,5-dimethyl-thiophene-3-carbaldehyde (887575-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Br₂; NaOAc / CH₂Cl₂ / 0 °C

2.1: nBuLi / diethyl ether / -78 °C

2.2: diethyl ether / -78 °C

With n-butyllithium; bromine; sodium acetate; In diethyl ether; dichloromethane;

DOI:10.1055/s-2002-35577

Reference yield:

4-bromo-2,5-dimethyl-thiophene-3-carbaldehyde (887575-78-2) → 4-bromo-2,5-dimethyl-thiophene-3-carboxylic acid (518330-09-1)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In acetone;

DOI:10.1055/s-2002-35577

upstream raw materials:

3,4-dibromo-2,5-dimethylthiophene

N,N-dimethyl-formamide

2,5-DIMETHYLTHIOPHENE

Downstream raw materials:

4-bromo-2,5-dimethyl-thiophene-3-carboxylic acid

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