[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

Base Information

Chemical Name:[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid
CAS No.:140702-19-8
Molecular Formula:C₃₇H₅₃N₇O₁₀S
Molecular Weight:787.935
Hs Code.:

[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

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Chemical Property of [(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

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Technology Process of [(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

There total 11 articles about [(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13673-51-3
N^α-Z-L-glutamine pentachlorophenyl ester

: 140702-19-8
[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 57.8 percent / triethylamine / dimethylformamide

2: H₂ / Pd/C / dimethylformamide

3: dimethylformamide

4: 74 percent / H₂ / Pd/C / dimethylformamide

5: 75.6 percent / triethylamine / dimethylformamide

6: 96 percent / 4 M HCl in acetic acid / 1 h

7: 95.8 percent / dimethylformamide

8: 4 M HCl in acetic acid / 0.25 h

9: triethylamine / dimethylformamide / 5 h / pH 7.5

10: 4 M HCl / dioxane / 0.5 h

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 64642-74-6
H-Gln-Gly-O^tBu

: 140702-19-8
[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: dimethylformamide

2: 74 percent / H₂ / Pd/C / dimethylformamide

3: 75.6 percent / triethylamine / dimethylformamide

4: 96 percent / 4 M HCl in acetic acid / 1 h

5: 95.8 percent / dimethylformamide

6: 4 M HCl in acetic acid / 0.25 h

7: triethylamine / dimethylformamide / 5 h / pH 7.5

8: 4 M HCl / dioxane / 0.5 h

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: Z-Gln-Gly-O^tBu

: 140702-19-8
[(S)-2-((S)-2-{(2S,3R)-2-[(2S,3R)-2-((S)-2-Amino-4-methylsulfanyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-butyrylamino}-propionylamino)-4-carbamoyl-butyrylamino]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Pd/C / dimethylformamide

2: dimethylformamide

3: 74 percent / H₂ / Pd/C / dimethylformamide

4: 75.6 percent / triethylamine / dimethylformamide

5: 96 percent / 4 M HCl in acetic acid / 1 h

6: 95.8 percent / dimethylformamide

7: 4 M HCl in acetic acid / 0.25 h

8: triethylamine / dimethylformamide / 5 h / pH 7.5

9: 4 M HCl / dioxane / 0.5 h

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide;