3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester

Base Information

• Chemical Name: 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester
• CAS No.: 81691-48-7
• Molecular Formula: C₆₆H₇₀ClN₁₀O₁₅PSi₂
• Molecular Weight: 1365.94
• Mol file: 81691-48-7.mol

Synonyms:

Chemical Property of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester

There total 6 articles about 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6,N6,2'-O,3'-O-tetrabenzoyladenosine (58463-04-0) + 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine 2'-(2-chlorophenyl) phosphomonotriazolide (81705-89-7) → 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester (81691-48-7)

Guidance literature:

With dmap; In pyridine; at 37 ℃; for 24h; Yield given;

Reference yield:

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine (69304-45-6) → 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester (81691-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 20 h / 37 °C

2: 4-(dimethylamino)pyridine / pyridine / 24 h / 37 °C

With pyridine; dmap; In tetrahydrofuran; pyridine;

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenylyl-(2'->5')-2',3'-di-O-benzoyl-N,N-dibenzoyladenosine P (2-chlorophenyl) ester (81691-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / pyridine / 20 h / 20 °C

2: pyridine / tetrahydrofuran / 20 h / 37 °C

3: 4-(dimethylamino)pyridine / pyridine / 24 h / 37 °C

With pyridine; dmap; In tetrahydrofuran; pyridine;

upstream raw materials:

N6,N6,2'-O,3'-O-tetrabenzoyladenosine

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine 2'-(2-chlorophenyl) phosphomonotriazolide

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

C₆₆H₇₂ClN₁₀O₁₆PSi₂