6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester
CAS No.:191853-48-2
Molecular Formula:C₈₇H₇₅N₅O₆
Molecular Weight:1286.58
Hs Code.:

6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

There total 4 articles about 6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24324-17-2
9-Fluorenylmethanol

: 191853-43-7
6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid

: 191853-48-2
6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 191853-48-2
6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / 1.) NaH; 2.) NaI / acetonitrile / 1.) room temp., 10 min; 2.) overnight

2: 94 percent / 1M NaOH / tetrahydrofuran; ethanol / 24 h / Ambient temperature

3: 67 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; sodium hydroxide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-42-6
6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid ethyl ester

: 191853-48-2
6-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-hexanoic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 1M NaOH / tetrahydrofuran; ethanol / 24 h / Ambient temperature

2: 67 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/hlca.19970800313