2-(Thiophen-3-yl)acetaMide

Base Information

• Chemical Name: 2-(Thiophen-3-yl)acetaMide
• CAS No.: 13781-66-3
• Molecular Formula: C6H7NOS
• Molecular Weight: 141.194
• Hs Code.: 2934999090
• Mol file: 13781-66-3.mol

Synonyms:2-thiophen-3-yl-acetamide;thiophene-3-acetamide;3-thiopheneacetamide;

Chemical Property of 2-(Thiophen-3-yl)acetaMide

Chemical Property:

• PSA: 71.33000
• LogP: 1.47620

Purity/Quality:

99% ^*data from raw suppliers

2-(thiophen-3-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 2-(Thiophen-3-yl)acetaMide

There total 4 articles about 2-(Thiophen-3-yl)acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

thiophen-3-yl-acetic acid (6964-21-2) → 2-(thiophene-3-yl) acetamide (13781-66-3)

Guidance literature:

With titanium tetrachloride; ammonium carbamate; In tetrahydrofuran; at 100 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1002/adsc.201200436

Reference yield: 88.0%

(thiophen-3-yl)acetonitrile (13781-53-8) → 2-(thiophene-3-yl) acetamide (13781-66-3)

Guidance literature:

With water; at 130 ℃; for 1h; Microwave irradiation;

DOI:10.1002/adsc.201600199

Reference yield:

1-(thiophen-3-yl)-ethanone (1468-83-3) → 2-(thiophene-3-yl) acetamide (13781-66-3)

Guidance literature:

With 1,4-dioxane; ammonium polysulfide; sulfur; at 160 ℃;

DOI:10.1021/ja01150a103

upstream raw materials:

1-(thiophen-3-yl)-ethanone

thiophen-3-yl-acetic acid

(thiophen-3-yl)acetonitrile

Downstream raw materials:

thiophen-3-yl-acetic acid

thiophene-3-methylamine methyl carbamate

(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

(4-(4-(4-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-butyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid