(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

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Chemical Name:(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid
CAS No.:1262304-45-9
Molecular Formula:C₂₉H₂₃N₅O₄S
Molecular Weight:537.599
Hs Code.:

Synonyms:(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

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Chemical Property of (4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

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Technology Process of (4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

There total 3 articles about (4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262304-15-3
C₂₁H₁₆N₂O₂S

: 62893-37-2
2-(4-azidophenyl)acetic acid

: 1262304-45-9
(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol; at 100 ℃; for 0.333333h; Microwave irradiation; Combinatorial reaction / High throughput screening (HTS);
DOI:10.1039/c0cc01166e

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1262304-45-9
(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; acetonitrile; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation; Combinatorial reaction / High throughput screening (HTS)

With tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c0cc01166e

Reference yield:

: 13781-66-3
2-(thiophene-3-yl) acetamide

: 942434-85-7
methyl 2-oxo-2-(1-(pent-4-yn-1-yl)-1H-indol-3-yl)acetate

: 1262304-45-9
(4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; acetonitrile; tert-butyl alcohol / 0.33 h / 100 °C / Microwave irradiation; Combinatorial reaction / High throughput screening (HTS)

With copper(ll) sulfate pentahydrate; potassium tert-butylate; sodium L-ascorbate; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c0cc01166e