Technology Process of (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-oct-5-enoic acid methyl ester
There total 10 articles about (Z)-(R)-8-(tert-Butyl-diphenyl-silanyloxy)-8-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-oct-5-enoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 4-dimethylaminopyridine / diethyl ether / 1.5 h / Ambient temperature
2: tributyltin hydride / toluene / 16 h / Heating
3: 0.02 M methanolic sodium methoxide / 2 h / Ambient temperature
4: 1.) p-toluenesulfonyl chloride, pyridine, 2.) 1.17 N aq. KOH / 1.) CHCl3, -50 deg C, 3 h; room temperature, 20 h, 2.) MeOH
5: n-BuLi / hexamethylphosphoric acid triamide / 20 h / Ambient temperature
6: diethyl ether
7: hydrogen, ethylene diamine / nickel acetate/sodium borohydride / ethanol
8: imidazole / dimethylformamide / 17 h / 78 °C
With
pyridine; 1H-imidazole; dmap; potassium hydroxide; n-butyllithium; hydrogen; tri-n-butyl-tin hydride; sodium methylate; ethylenediamine; p-toluenesulfonyl chloride;
sodium tetrahydroborate; nickel diacetate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: n-BuLi / hexamethylphosphoric acid triamide / 20 h / Ambient temperature
2: diethyl ether
3: hydrogen, ethylene diamine / nickel acetate/sodium borohydride / ethanol
4: imidazole / dimethylformamide / 17 h / 78 °C
With
1H-imidazole; n-butyllithium; hydrogen; ethylenediamine;
sodium tetrahydroborate; nickel diacetate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) p-toluenesulfonyl chloride, pyridine, 2.) 1.17 N aq. KOH / 1.) CHCl3, -50 deg C, 3 h; room temperature, 20 h, 2.) MeOH
2: n-BuLi / hexamethylphosphoric acid triamide / 20 h / Ambient temperature
3: diethyl ether
4: hydrogen, ethylene diamine / nickel acetate/sodium borohydride / ethanol
5: imidazole / dimethylformamide / 17 h / 78 °C
With
pyridine; 1H-imidazole; potassium hydroxide; n-butyllithium; hydrogen; ethylenediamine; p-toluenesulfonyl chloride;
sodium tetrahydroborate; nickel diacetate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; N,N-dimethyl-formamide;
