[5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester
• CAS No.: 157837-22-4
• Molecular Formula: C₂₄H₂₆N₄O₄
• Molecular Weight: 434.495
• Mol file: 157837-22-4.mol

Synonyms:

Chemical Property of [5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

There total 1 articles about [5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetopyrrolidine (90892-09-4) + 1,3-dihydro-5-methyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one (157837-04-2) → [5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (157837-22-4)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

[5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (157837-22-4) → (3-{3-[5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-ureido}-benzyloxycarbonylamino)-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr / Ambient temperature

2: Et₃N / CH₂Cl₂ / 3 h

3: aq. NaOH / methanol / 2 h / 0 °C

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00074-6

Reference yield:

[5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (157837-22-4) → (3-{3-[5-Methyl-2-oxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-ureido}-benzyloxycarbonylamino)-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr / Ambient temperature

2: Et₃N / CH₂Cl₂ / 3 h

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00074-6

upstream raw materials:

bromoacetopyrrolidine

1,3-dihydro-5-methyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one