Technology Process of 3-Quinolinecarboxylicacid,6-amino-1-cyclopropyl-7-(3,4-dihydro-2(1H)-isoquinolinyl)-1,4-dihydro-8-methyl-4-oxo-
There total 9 articles about 3-Quinolinecarboxylicacid,6-amino-1-cyclopropyl-7-(3,4-dihydro-2(1H)-isoquinolinyl)-1,4-dihydro-8-methyl-4-oxo- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
nickel;
In
2-methoxy-ethanol;
for 1h;
under 760 Torr;
Yield given;
Ambient temperature;
DOI:10.1021/jm950558v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 38 percent / Et3N / acetonitrile / 40 h / Heating
2: H2 / Raney Ni / 2-methoxy-ethanol / 1 h / 760 Torr / Ambient temperature
With
hydrogen; triethylamine;
nickel;
In
2-methoxy-ethanol; acetonitrile;
DOI:10.1021/jm950558v
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) AlCl3, 2.) Br2, NaOH, 3.) 99.5percent HNO3, 98percent H2SO4
2: SOCl2 / 3 h / Heating
3: Et3N / toluene / 2 h / 90 °C
4: ethanol; diethyl ether / 0.25 h / Ambient temperature
5: K2CO3 / dimethylformamide / 0.67 h / 100 °C
6: 90 percent / 6N aq. HCl / ethanol / 2 h / Heating
7: 38 percent / Et3N / acetonitrile / 40 h / Heating
8: H2 / Raney Ni / 2-methoxy-ethanol / 1 h / 760 Torr / Ambient temperature
With
hydrogenchloride; sodium hydroxide; aluminium trichloride; thionyl chloride; sulfuric acid; hydrogen; bromine; nitric acid; potassium carbonate; triethylamine;
nickel;
In
diethyl ether; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm950558v
