2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
CAS No.:210988-85-5
Molecular Formula:C₅₂H₄₉N₇O₆
Molecular Weight:868.004
Hs Code.:

2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Chemical Property of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Technology Process of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

There total 10 articles about 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 210988-85-5
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / pyridine / 1.5 h

2: 71 percent / NaH / dimethylformamide / Ambient temperature

3: 91 percent / AcOH / ethanol / 3 h / Heating

4: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

5: 86 percent / Et₃N / dimethylformamide

6: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: ethyl N-cyanovalerimidate

: 210988-85-5
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / ethanol / Ambient temperature

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: NaH / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / pyridine / 1.5 h

5: 71 percent / NaH / dimethylformamide / Ambient temperature

6: 91 percent / AcOH / ethanol / 3 h / Heating

7: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

8: 86 percent / Et₃N / dimethylformamide

9: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: 133614-30-9
N-(N'-cyanovalerimidolyl)glycine ethyl ester

: 210988-85-5
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

2: NaH / dimethylformamide / 3 h / Ambient temperature

3: 72 percent / pyridine / 1.5 h

4: 71 percent / NaH / dimethylformamide / Ambient temperature

5: 91 percent / AcOH / ethanol / 3 h / Heating

6: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

7: 86 percent / Et₃N / dimethylformamide

8: 1.) 0.1N ethanolic KOH, 2.) 10percent aq. NaI / 2.) acetone, reflux

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973