2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

Base Information

Chemical Name:2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran
CAS No.:1616561-89-7
Molecular Formula:C₁₆H₂₄O₂
Molecular Weight:248.365
Hs Code.:

Synonyms:

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Chemical Property of 2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

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Technology Process of 2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

There total 6 articles about 2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1616561-78-4
5-(3-phenylpropoxy)hept-6-en-1-ol

: 1616561-89-7
2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

Guidance literature:: With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); diphenyl hydrogen phosphate; In toluene; at 20 - 115 ℃; for 23h; Inert atmosphere;
DOI:10.1002/chem.201304270

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 1616561-89-7
2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / -78 - 20 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / toluene; 1,2-dimethoxyethane / 0.25 h / 0 - 50 °C / Inert atmosphere

4.2: 2 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

6.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); diphenyl hydrogen phosphate / toluene / 23 h / 20 - 115 °C / Inert atmosphere

With 1H-imidazole; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); oxalyl dichloride; diphenyl hydrogen phosphate; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201304270

Reference yield:

: 87184-80-3
5-tert-butyldimethylsilyloxypentanal

: 1616561-89-7
2-ethyl-2-(3-phenylpropoxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / toluene; 1,2-dimethoxyethane / 0.25 h / 0 - 50 °C / Inert atmosphere

2.2: 2 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

4.1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); diphenyl hydrogen phosphate / toluene / 23 h / 20 - 115 °C / Inert atmosphere

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); diphenyl hydrogen phosphate; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; toluene;
DOI:10.1002/chem.201304270