ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate

Base Information

• Chemical Name: ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate
• CAS No.: 1215021-47-8
• Molecular Formula: C₁₃H₁₄O₄
• Molecular Weight: 234.252
• Mol file: 1215021-47-8.mol

Synonyms:

Chemical Property of ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate

There total 1 articles about ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl (R)-(-)-2-hydroxy-4-oxo-4-phenylbutanoate (244277-48-3) → ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate (1215021-47-8)

Guidance literature:

With morpholine; In acetic acid; for 2h; optical yield given as %ee; Inert atmosphere; Molecular sieve; Reflux;

DOI:10.1021/jo902227f

Reference yield:

ethyl (R)-(-)-2-hydroxy-3-methylene-4-oxophenylbutanoate (1215021-47-8) → ethyl (2R,3S)-2-hydroxy-3-methyl-4-oxo-4-phenylbutanoate + 2-hydroxy-3-methyl-4-oxo-4-phenylbutyric acid ethyl ester

Guidance literature:

With Rhodotorula glutinis CCT 2182; In ethanol; at 30 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/jo902227f

upstream raw materials:

formaldehyd

ethyl (R)-(-)-2-hydroxy-4-oxo-4-phenylbutanoate